A dynamic clamping approach using in silico IK1 current for discrimination of chamber-specific hiPSC-derived cardiomyocytes

Claudia Altomare; Chiara Bartolucci; Luca Sala; Carolina Balbi; Jacopo Burrello; Nicole Pietrogiovanna; Alessio Burrello; Sara Bolis; Stefano Panella; Martina Arici; Rolf Krause; Marcella Rocchetti; Stefano Severi; Lucio Barile

doi:10.1038/s42003-023-04674-9

Communications Biology (Mar 2023)

A dynamic clamping approach using in silico IK1 current for discrimination of chamber-specific hiPSC-derived cardiomyocytes

Claudia Altomare,
Chiara Bartolucci,
Luca Sala,
Carolina Balbi,
Jacopo Burrello,
Nicole Pietrogiovanna,
Alessio Burrello,
Sara Bolis,
Stefano Panella,
Martina Arici,
Rolf Krause,
Marcella Rocchetti,
Stefano Severi,
Lucio Barile

Affiliations

Claudia Altomare: Cardiovascular Theranostics, Istituto Cardiocentro Ticino, Ente Ospedaliero Cantonale
Chiara Bartolucci: Department of Electrical, Electronic and Information Engineering ‘Guglielmo Marconi’, University of Bologna
Luca Sala: Istituto Auxologico Italiano IRCCS, Center for Cardiac Arrhythmias of Genetic Origin and Laboratory of Cardiovascular Genetics
Carolina Balbi: Laboratories for Translational Research, Ente Ospedaliero Cantonale
Jacopo Burrello: Cardiovascular Theranostics, Istituto Cardiocentro Ticino, Ente Ospedaliero Cantonale
Nicole Pietrogiovanna: Cardiovascular Theranostics, Istituto Cardiocentro Ticino, Ente Ospedaliero Cantonale
Alessio Burrello: Department of Electrical, Electronic and Information Engineering (DEI), University of Bologna
Sara Bolis: Cardiovascular Theranostics, Istituto Cardiocentro Ticino, Ente Ospedaliero Cantonale
Stefano Panella: Cardiovascular Theranostics, Istituto Cardiocentro Ticino, Ente Ospedaliero Cantonale
Martina Arici: Department of Biotechnology and Biosciences, University of Milano-Bicocca
Rolf Krause: Euler institute, Università Svizzera italiana
Marcella Rocchetti: Department of Biotechnology and Biosciences, University of Milano-Bicocca
Stefano Severi: Department of Electrical, Electronic and Information Engineering ‘Guglielmo Marconi’, University of Bologna
Lucio Barile: Cardiovascular Theranostics, Istituto Cardiocentro Ticino, Ente Ospedaliero Cantonale

DOI: https://doi.org/10.1038/s42003-023-04674-9
Journal volume & issue: Vol. 6, no. 1
pp. 1 – 13

Abstract

Read online

An in silico hybrid model to derive electrical biomarkers to be used as inputs for an unsupervised learning algorithm to classify differentiated hiPSC-derived cardiomyocytes from a mixed population of ventricular- and atrial-like cells.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal