CD44: a cancer stem cell marker and therapeutic target in leukemia treatment

Shuang Wu; Shuang Wu; Yicheng Tan; Yicheng Tan; Yicheng Tan; Fanfan Li; Fanfan Li; Fanfan Li; Yixiang Han; Yixiang Han; Yixiang Han; Shenghui Zhang; Shenghui Zhang; Shenghui Zhang; Shenghui Zhang; Xiaofei Lin

doi:10.3389/fimmu.2024.1354992

Frontiers in Immunology (Apr 2024)

CD44: a cancer stem cell marker and therapeutic target in leukemia treatment

Shuang Wu,
Shuang Wu,
Yicheng Tan,
Yicheng Tan,
Yicheng Tan,
Fanfan Li,
Fanfan Li,
Fanfan Li,
Yixiang Han,
Yixiang Han,
Yixiang Han,
Shenghui Zhang,
Shenghui Zhang,
Shenghui Zhang,
Shenghui Zhang,
Xiaofei Lin

Affiliations

Shuang Wu: Laboratory Animal Center, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China
Shuang Wu: Institute of Hematology, Wenzhou Medical University, Wenzhou, Zhejiang, China
Yicheng Tan: Laboratory Animal Center, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China
Yicheng Tan: Institute of Hematology, Wenzhou Medical University, Wenzhou, Zhejiang, China
Yicheng Tan: Wenzhou Key laboratory of Hematology, Wenzhou, Zhejiang, China
Fanfan Li: Institute of Hematology, Wenzhou Medical University, Wenzhou, Zhejiang, China
Fanfan Li: Wenzhou Key laboratory of Hematology, Wenzhou, Zhejiang, China
Fanfan Li: Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China
Yixiang Han: Institute of Hematology, Wenzhou Medical University, Wenzhou, Zhejiang, China
Yixiang Han: Wenzhou Key laboratory of Hematology, Wenzhou, Zhejiang, China
Yixiang Han: Central Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China
Shenghui Zhang: Laboratory Animal Center, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China
Shenghui Zhang: Institute of Hematology, Wenzhou Medical University, Wenzhou, Zhejiang, China
Shenghui Zhang: Wenzhou Key laboratory of Hematology, Wenzhou, Zhejiang, China
Shenghui Zhang: Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China
Xiaofei Lin: Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China

DOI: https://doi.org/10.3389/fimmu.2024.1354992
Journal volume & issue: Vol. 15

Abstract

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CD44 is a ubiquitous leukocyte adhesion molecule involved in cell-cell interaction, cell adhesion, migration, homing and differentiation. CD44 can mediate the interaction between leukemic stem cells and the surrounding extracellular matrix, thereby inducing a cascade of signaling pathways to regulate their various behaviors. In this review, we focus on the impact of CD44s/CD44v as biomarkers in leukemia development and discuss the current research and prospects for CD44-related interventions in clinical application.

Published in Frontiers in Immunology

ISSN: 1664-3224 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: http://journal.frontiersin.org/journal/immunology

About the journal

Abstract

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