Real-time interactive planning for radiotherapy of head and neck cancer with volumetric modulated arc therapy

Abstract

Background and purpose: Planning complex radiotherapy treatments can be inefficient, with large variation in plan quality. In this study we evaluated plan quality and planning efficiency using real-time interactive planning (RTIP) for head and neck (HN) volumetric modulated arc therapy (VMAT). Materials and methods: RTIP allows manipulation of dose volume histograms (DVHs) in real-time to assess achievable planning target volume (PTV) coverage and organ at risk (OAR) sparing. For 20 HN patients previously treated with VMAT, RTIP was used to minimize OAR dose while maintaining PTV coverage. RTIP DVHs were used to guide VMAT optimization. Dosimetric differences between RTIP-assisted plans and original clinical plans were assessed. Five blinded radiation oncologists indicated their preference for each PTV, OAR and overall plan. To assess efficiency, ten patients were planned de novo by experienced and novice planners and a RTIP user. Results: The average planning time with RTIP was <20 min, and most plans required only one optimization. All 20 RTIP plans were preferred by a majority of oncologists due to improvements in OAR sparing. The average maximum dose to the spinal cord was reduced by 10.5 Gy (from 49.5 to 39.0 Gy), and the average mean doses for the oral cavity, laryngopharynx, contralateral parotid and submandibular glands were reduced by 3.5 Gy (39.1–35.7 Gy), 6.8 Gy (42.5–35.7 Gy), 1.7 Gy (17.0–15.3 Gy) and 3.3 Gy (22.9–19.5 Gy), respectively. Conclusions: Incorporating RTIP into clinical workflows may increase both planning efficiency and OAR sparing. Keywords: Volumetric modulated arc therapy, Real-time planning, Head and neck, Optimization, Radiotherapy treatment planning