Nature Communications (May 2022)
Integrative proteogenomic characterization of hepatocellular carcinoma across etiologies and stages
- Charlotte K. Y. Ng,
- Eva Dazert,
- Tuyana Boldanova,
- Mairene Coto-Llerena,
- Sandro Nuciforo,
- Caner Ercan,
- Aleksei Suslov,
- Marie-Anne Meier,
- Thomas Bock,
- Alexander Schmidt,
- Sylvia Ketterer,
- Xueya Wang,
- Stefan Wieland,
- Matthias S. Matter,
- Marco Colombi,
- Salvatore Piscuoglio,
- Luigi M. Terracciano,
- Michael N. Hall,
- Markus H. Heim
Affiliations
- Charlotte K. Y. Ng
- Department of Biomedicine, University Hospital Basel, University of Basel
- Eva Dazert
- Biozentrum, University of Basel
- Tuyana Boldanova
- Department of Biomedicine, University Hospital Basel, University of Basel
- Mairene Coto-Llerena
- Department of Biomedicine, University Hospital Basel, University of Basel
- Sandro Nuciforo
- Department of Biomedicine, University Hospital Basel, University of Basel
- Caner Ercan
- Institute of Medical Genetics and Pathology, University Hospital Basel, University of Basel
- Aleksei Suslov
- Department of Biomedicine, University Hospital Basel, University of Basel
- Marie-Anne Meier
- Department of Biomedicine, University Hospital Basel, University of Basel
- Thomas Bock
- Biozentrum, University of Basel
- Alexander Schmidt
- Biozentrum, University of Basel
- Sylvia Ketterer
- Department of Biomedicine, University Hospital Basel, University of Basel
- Xueya Wang
- Department of Biomedicine, University Hospital Basel, University of Basel
- Stefan Wieland
- Department of Biomedicine, University Hospital Basel, University of Basel
- Matthias S. Matter
- Institute of Medical Genetics and Pathology, University Hospital Basel, University of Basel
- Marco Colombi
- Biozentrum, University of Basel
- Salvatore Piscuoglio
- Department of Biomedicine, University Hospital Basel, University of Basel
- Luigi M. Terracciano
- Institute of Medical Genetics and Pathology, University Hospital Basel, University of Basel
- Michael N. Hall
- Biozentrum, University of Basel
- Markus H. Heim
- Department of Biomedicine, University Hospital Basel, University of Basel
- DOI
- https://doi.org/10.1038/s41467-022-29960-8
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 18
Abstract
Proteogenomic analyses of hepatocellular carcinomas (HCC) have focused on early-stage, HBV-associated tumours and lacked information about the phosphoproteome. Here, the authors present a comprehensive HCC proteogenomics and phosphoproteomics study in patient samples from multiple etiologies and stages.
