Nature Communications (Dec 2020)

High-speed atomic force microscopy highlights new molecular mechanism of daptomycin action

  • Francesca Zuttion,
  • Adai Colom,
  • Stefan Matile,
  • Denes Farago,
  • Frédérique Pompeo,
  • Janos Kokavecz,
  • Anne Galinier,
  • James Sturgis,
  • Ignacio Casuso

DOI
https://doi.org/10.1038/s41467-020-19710-z
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 16

Abstract

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High-speed atomic force imaging allows for the visualisation of molecular‐level activity in real-time. Here, the authors use HS-AFM to image the activity of an antimicrobial peptide on a membrane and are able to detect previously unknown molecular mechanisms behind its action.