A widely distributed family of eukaryotic and bacterial deubiquitinases related to herpesviral large tegument proteins

Ilka Erven; Elena Abraham; Thomas Hermanns; Ulrich Baumann; Kay Hofmann

doi:10.1038/s41467-022-35244-y

Nature Communications (Dec 2022)

A widely distributed family of eukaryotic and bacterial deubiquitinases related to herpesviral large tegument proteins

Ilka Erven,
Elena Abraham,
Thomas Hermanns,
Ulrich Baumann,
Kay Hofmann

Affiliations

Ilka Erven: Institute for Genetics, University of Cologne
Elena Abraham: Institute of Biochemistry, University of Cologne
Thomas Hermanns: Institute for Genetics, University of Cologne
Ulrich Baumann: Institute of Biochemistry, University of Cologne
Kay Hofmann: Institute for Genetics, University of Cologne

DOI: https://doi.org/10.1038/s41467-022-35244-y
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 17

Abstract

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The authors describe the VTD-deubiquitinases, a new eukaryotic enzyme family that is distantly related to herpesviral large tegument proteins. Structures of two family members with different linkage preferences allow insights into the mechanism and chain-specificity of this unusual deubiquitinase class.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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