BMJ Open (Jul 2023)

Prevalence, management and efficacy of treatment in portal vein obstruction after paediatric liver transplantation: protocol of the retrospective international multicentre PORTAL registry

  • Barbara E Wildhaber,
  • Martin de Santibañes,
  • Victoria Ardiles,
  • Ruben H J de Kleine,
  • Raj Prasad,
  • Bhargava Mullapudi,
  • Jai Patel,
  • Reinoud P H Bokkers,
  • Ekkehard Sturm,
  • Simon McGuirk,
  • Girish Gupte,
  • John McCall,
  • Richard J Hendrickson,
  • Winita Hardikar,
  • Helen Evans,
  • Khalid Sharif,
  • Marumbo Mtegha,
  • Amar Mukund,
  • David Duncan,
  • Emmanuel Gonzales,
  • Marco Spada,
  • Mureo Kasahara,
  • Denise Aldrian,
  • Bader A Alfares,
  • Hubert P J van der Doef,
  • Thomas Casswall,
  • Greg Nowak,
  • Martin Delle,
  • Valeria Berchtold,
  • Georg F Vogel,
  • Piotr Kaliciński,
  • Malgorzata Markiewicz-Kijewska,
  • Adam Kolesnik,
  • Jesús Q Bernabeu,
  • María Mercadal Hally,
  • Mauricio Larrarte K,
  • Paolo Marra,
  • Michela Bravi,
  • Domenico Pinelli,
  • Seisuke Sakamoto,
  • Hajime Uchida,
  • Vidyadhar Mali,
  • Marion Aw,
  • Stéphanie Franchi-Abella,
  • Florent Guérin,
  • Guillermo Cervio,
  • Julia Minetto,
  • Sergio Sierre,
  • Jimmy Walker Uno,
  • Steffen Hartleif,
  • Cristina T Ferreira,
  • Luiza S Nader,
  • Marco Farina,
  • Catalina Jaramillo,
  • Manuel I Rodriguez-Davalos,
  • Peter Feola,
  • Amit A Shah,
  • Phoebe M Wood,
  • Michael R Acord,
  • Ryan T Fischer,
  • Rajeev Khanna,
  • Viniyendra Pamecha,
  • Gilda Porta,
  • Tommaso Alterio,
  • Giuseppe Maggiore,
  • Marisa Beretta,
  • Rudi Dierckx

DOI
https://doi.org/10.1136/bmjopen-2022-066343
Journal volume & issue
Vol. 13, no. 7

Abstract

Read online

Introduction Portal vein obstruction (PVO) consists of anastomotic stenosis and thrombosis, which occurs due to a progression of the former. The aim of this large-scale international study is to assess the prevalence, current management practices and efficacy of treatment in patients with PVO.Methods and analysis The Portal vein Obstruction Revascularisation Therapy After Liver transplantation registry will facilitate an international, retrospective, multicentre, observational study, with 25 centres around the world already actively involved. Paediatric patients (aged <18 years) with a diagnosed PVO between 1 January 2001 and 1 January 2021 after liver transplantation will be eligible for inclusion. The primary endpoints are the prevalence of PVO, primary and secondary patency after PVO intervention and current management practices. Secondary endpoints are patient and graft survival, severe complications of PVO and technical success of revascularisation techniques.Ethics and dissemination Medical Ethics Review Board of the University Medical Center Groningen has approved the study (METc 2021/072). The results of this study will be disseminated via peer-reviewed publications and scientific presentations at national and international conferences.Trial registration number Netherlands Trial Register (NL9261).