Nature Communications (Sep 2018)

The chromatin remodeler RSF1 controls centromeric histone modifications to coordinate chromosome segregation

  • Ho-Soo Lee,
  • Zhonghui Lin,
  • Sunyoung Chae,
  • Young-Suk Yoo,
  • Byung-Gyu Kim,
  • Youngsoo Lee,
  • Jared L. Johnson,
  • You-Sun Kim,
  • Lewis C. Cantley,
  • Chang-Woo Lee,
  • Hongtao Yu,
  • Hyeseong Cho

DOI
https://doi.org/10.1038/s41467-018-06377-w
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 13

Abstract

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The chromatin remodeler RSF1 is enriched at mitotic centromeres but its function there is poorly understood. Here, the authors show that RSF1 regulates H2A phosphorylation and acetylation at mitotic centromeres and contributes to chromosome stability.