Nature Communications (Apr 2017)
Dopamine neuronal loss contributes to memory and reward dysfunction in a model of Alzheimer’s disease
- Annalisa Nobili,
- Emanuele Claudio Latagliata,
- Maria Teresa Viscomi,
- Virve Cavallucci,
- Debora Cutuli,
- Giacomo Giacovazzo,
- Paraskevi Krashia,
- Francesca Romana Rizzo,
- Ramona Marino,
- Mauro Federici,
- Paola De Bartolo,
- Daniela Aversa,
- Maria Concetta Dell’Acqua,
- Alberto Cordella,
- Marco Sancandi,
- Flavio Keller,
- Laura Petrosini,
- Stefano Puglisi-Allegra,
- Nicola Biagio Mercuri,
- Roberto Coccurello,
- Nicola Berretta,
- Marcello D’Amelio
Affiliations
- Annalisa Nobili
- Department of Experimental Neurosciences, IRCCS Santa Lucia Foundation
- Emanuele Claudio Latagliata
- Department of Experimental Neurosciences, IRCCS Santa Lucia Foundation
- Maria Teresa Viscomi
- Department of Experimental Neurosciences, IRCCS Santa Lucia Foundation
- Virve Cavallucci
- Department of Experimental Neurosciences, IRCCS Santa Lucia Foundation
- Debora Cutuli
- Department of Experimental Neurosciences, IRCCS Santa Lucia Foundation
- Giacomo Giacovazzo
- Department of Experimental Neurosciences, IRCCS Santa Lucia Foundation
- Paraskevi Krashia
- Department of Experimental Neurosciences, IRCCS Santa Lucia Foundation
- Francesca Romana Rizzo
- Department of Experimental Neurosciences, IRCCS Santa Lucia Foundation
- Ramona Marino
- Department of Medicine, Unit of Molecular Neurosciences, University Campus-Biomedico
- Mauro Federici
- Department of Experimental Neurosciences, IRCCS Santa Lucia Foundation
- Paola De Bartolo
- Department of Experimental Neurosciences, IRCCS Santa Lucia Foundation
- Daniela Aversa
- Department of Experimental Neurosciences, IRCCS Santa Lucia Foundation
- Maria Concetta Dell’Acqua
- Department of Experimental Neurosciences, IRCCS Santa Lucia Foundation
- Alberto Cordella
- Department of Experimental Neurosciences, IRCCS Santa Lucia Foundation
- Marco Sancandi
- Department of Psychology, University Sapienza
- Flavio Keller
- Department of Medicine, Laboratory of Developmental Neuroscience and Neural Plasticity, University Campus-Biomedico
- Laura Petrosini
- Department of Experimental Neurosciences, IRCCS Santa Lucia Foundation
- Stefano Puglisi-Allegra
- Department of Experimental Neurosciences, IRCCS Santa Lucia Foundation
- Nicola Biagio Mercuri
- Department of Experimental Neurosciences, IRCCS Santa Lucia Foundation
- Roberto Coccurello
- Department of Experimental Neurosciences, IRCCS Santa Lucia Foundation
- Nicola Berretta
- Department of Experimental Neurosciences, IRCCS Santa Lucia Foundation
- Marcello D’Amelio
- Department of Experimental Neurosciences, IRCCS Santa Lucia Foundation
- DOI
- https://doi.org/10.1038/ncomms14727
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 14
Abstract
Dopaminergic dysfunction occurs in Alzheimer’s disease (AD). The authors show that in a mouse model of AD, loss of dopaminergic neurons in the ventral tegmental area, but not the substantia nigra, occurs at early pre-plaque stages, and may contribute to impaired cognition and reward processing.
