Антибиотики и Химиотерапия (May 2020)

Antibiotic Activity of Probiotic Strain Bacillus subtilis 534 Against Clinical Isolates of Acinetobacter baumannii

  • O. V. Efremenkova,
  • N. I. Gabrielyan,
  • I. A. Malanicheva,
  • T. A. Efimenko,
  • L. P. Terekhova,
  • V. V. Udalova,
  • A. A. Glukhova,
  • E. A. Rogozhin,
  • V. A. Alferova,
  • V. A. Korshun,
  • M. Kh. Kubanova,
  • I. V. Drabkina,
  • T. V. Krupenio

Journal volume & issue
Vol. 61, no. 9-10
pp. 3 – 7

Abstract

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Probiotic strain Bacillus subtilis 534 is the base of sporobacterin, a pharmaceutical. In submerged culture it showed antibiotic activity against many of gram-positive and gram-negative bacteria and fungi. The spectrum of the antimicrobial activity of the culture fluid depended on the cultivation time and aeration intensity. It was shown that component No. 1 of the antibiotic complex was effective against clinical isolates of Acinetobacter baumannii: 20 out of 24 isolates were susceptible to component No. 1, including 15 strains out of 16 panresistant isolates.

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