International Journal of Molecular Sciences (May 2011)

Anticoagulant, Antioxidant and Antitumor Activities of Heterofucans from the Seaweed Dictyopteris delicatula

  • Hugo Alexandre Oliveira Rocha,
  • Luciana Guimaraes Alves,
  • Mariana Santana Santos Pereira Costa,
  • Diego Araujo Sabry,
  • Sara Lima Cordeiro,
  • Ivan Rui Lopes Albuquerque,
  • Rafael Barros Gomes Camara,
  • Leonardo Thiago Duarte Barreto Nobre,
  • Nednaldo Dantas-Santos,
  • Kaline Dantas Magalhaes,
  • Leandro Silva Costa,
  • Ruth Medeiros Oliveira,
  • Gabriel Pereira Fidelis

DOI
https://doi.org/10.3390/ijms12053352
Journal volume & issue
Vol. 12, no. 5
pp. 3352 – 3365

Abstract

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In the present study, six families of sulfated polysaccharides were obtained from seaweed Dictyopteris delicatula by proteolytic digestion, followed by acetone fractionation and molecular sieving on Sephadex G-100. Chemical analyses demonstrated that all polysaccharides contain heterofucans composed mainly of fucose, xylose, glucose, galactose, uronic acid, and sulfate. The fucans F0.5v and F0.7v at 1.0 mg/mL showed high ferric chelating activity (~45%), whereas fucans F1.3v (0.5 mg/mL) showed considerable reducing power, about 53.2% of the activity of vitamin C. The fucan F1.5v presented the most prominent anticoagulant activity. The best antiproliferative activity was found with fucans F1.3v and F0.7v. However, F1.3v activity was much higher than F0.7v inhibiting almost 100% of HeLa cell proliferation. These fucans have been selected for further studies on structural characterization as well as in vivo experiments, which are already in progress.

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