Nature Communications (Jan 2019)

A tumor-specific endogenous repetitive element is induced by herpesviruses

  • Maciej T. Nogalski,
  • Alexander Solovyov,
  • Anupriya S. Kulkarni,
  • Niyati Desai,
  • Adam Oberstein,
  • Arnold J. Levine,
  • David T. Ting,
  • Thomas Shenk,
  • Benjamin D. Greenbaum

DOI
https://doi.org/10.1038/s41467-018-07944-x
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 13

Abstract

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The human genome includes a large amount of repetitive sequence, such as human satellite II (HSATII), but their function remains largely unknown. Here, Nogalski et al. show that herpesvirus infection induces HSATII RNA expression, which in turn affects virus replication and cell motility.