Salud Pública de México (Jan 1999)

The epidemiology of Her-2/ neu and P53 in breast cancer

  • Bernstein Jonine L.,
  • López-Carrillo Lizbeth,
  • Wang Lisa

Journal volume & issue
Vol. 41, no. suppl.2
pp. S114 – S121

Abstract

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Breast cancer is an etiologically heterogeneous disease with marked geographical variations. Joint consideration of the relationship between specific molecular alterations and known or suspected epidemiologic risk factors for this disease should help distinguish subgroups of women that are at elevated risk of developing breast cancer. In this article, we present a comprehensive literature review of the etiologic and prognostic roles of Her-2/neu and P53 among women. In addition, we discuss the advantages and limitations of using biomarkers in epidemiological studies. We conclude that more research is needed to understand the complex relationships between genetic alterations and etiologic risk factors for breast cancer.

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