The Inflammatory Response in Cardiac Surgery. An Up-to-date Overview with the Emphasis on the Role of Heat Shock Proteins (HSPs) 60 and 70

Abstract

Cardiac surgical operations are associated with the development of a systemic inflammatory response syndrome (SIRS). In most cases, the inflammatory response is apparent only in its subclinical form. In some cases, however, it can become clinically manifest or even life-threatening. This review article presents some new data regarding its biological importance, along with an insight into the recently discovered role played by heat shock proteins 60 and 70.

Keywords

• Cardiac surgery
• Ischemia and reperfusion
• Inflammation
• Innate immunity
• Heat shock proteins
• Lipopolysaccharide