Highly plastic Zn-0.3Ca alloy for guided bone regeneration membrane: Breaking the trade-off between antibacterial ability and biocompatibility

Xiang-Min Li; Zhang-Zhi Shi; Ayisulu Tuoliken; Wei Gou; Chang-Heng Li; Lu-Ning Wang

Bioactive Materials (Dec 2024)

Highly plastic Zn-0.3Ca alloy for guided bone regeneration membrane: Breaking the trade-off between antibacterial ability and biocompatibility

Xiang-Min Li,
Zhang-Zhi Shi,
Ayisulu Tuoliken,
Wei Gou,
Chang-Heng Li,
Lu-Ning Wang

Affiliations

Xiang-Min Li: Beijing Advanced Innovation Center for Materials Genome Engineering, State Key Laboratory for Advance Metals and Materials, School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing, 100083, China
Zhang-Zhi Shi: Beijing Advanced Innovation Center for Materials Genome Engineering, State Key Laboratory for Advance Metals and Materials, School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing, 100083, China; Institute of Materials Intelligent Technology, Liaoning Academy of Materials, Shenyang, 110004, China; Corresponding author. Beijing Advanced Innovation Center for Materials Genome Engineering, State Key Laboratory for Advance Metals and Materials, School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing, 100083, China.
Ayisulu Tuoliken: Beijing Advanced Innovation Center for Materials Genome Engineering, State Key Laboratory for Advance Metals and Materials, School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing, 100083, China
Wei Gou: Beijing Advanced Innovation Center for Materials Genome Engineering, State Key Laboratory for Advance Metals and Materials, School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing, 100083, China
Chang-Heng Li: Beijing Advanced Innovation Center for Materials Genome Engineering, State Key Laboratory for Advance Metals and Materials, School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing, 100083, China
Lu-Ning Wang: Beijing Advanced Innovation Center for Materials Genome Engineering, State Key Laboratory for Advance Metals and Materials, School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing, 100083, China; Institute of Materials Intelligent Technology, Liaoning Academy of Materials, Shenyang, 110004, China; Corresponding author. Beijing Advanced Innovation Center for Materials Genome Engineering, State Key Laboratory for Advance Metals and Materials, School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing, 100083, China.

Journal volume & issue: Vol. 42
pp. 550 – 572

Abstract

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A common problem for Zn alloys is the trade-off between antibacterial ability and biocompatibility. This paper proposes a strategy to solve this problem by increasing release ratio of Ca2+ ions, which is realized by significant refinement of CaZn13 particles through bottom circulating water-cooled casting (BCWC) and rolling. Compared with conventionally fabricated Zn-0.3Ca alloy, the BCWC-rolled alloy shows higher antibacterial abilities against E. coli and S. aureus, meanwhile much less toxicity to MC3T3-E1 cells. Additionally, plasticity, degradation uniformity, and ability to induce osteogenic differentiation in vitro of the alloy are improved. The elongation up to 49 %, which is the highest among Zn alloys with Ca, and is achieved since the sizes of CaZn13 particles and Zn grains are small and close. As a result, the long-standing problem of low formability of Zn alloys containing Ca has also been solved due to the elimination of large CaZn13 particles. The BCWC-rolled alloy is a promising candidate of making GBR membrane.

Published in Bioactive Materials

ISSN: 2452-199X (Online)
Publisher: KeAi Communications Co., Ltd.
Country of publisher: China
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials; Science: Biology (General)
Website: https://www.keaipublishing.com/en/journals/bioactive-materials/

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