Cardiac magnetic resonance evaluation in recipients of hepatitis c virus-infected donor hearts
J. Lukas Laws, MD,
Benjamin Palmer, MD,
Jonathan H. Soslow, MD, MSCI,
Cassandra Hennessy, MS,
Richa Gupta, MD, MPH,
JoAnn Lindenfeld, MD,
Jeffrey M. Dendy, MD,
Dandan Liu, PhD,
Kelly H. Schlendorf, MD, MHS,
Daniel E. Clark, MD, MPH,
Sean G. Hughes, MD
Affiliations
J. Lukas Laws, MD
Vanderbilt University Medical Center, Division of Cardiovascular Medicine, Department of Internal Medicine, Nashville, Tennessee; Corresponding author: J. Lukas Laws, MD, Vanderbilt Heart and Vascular Institute, 1215 21st Ave South, Nashville, TN 37232.
Benjamin Palmer, MD
Vanderbilt University Medical Center, Division of Cardiovascular Medicine, Department of Internal Medicine, Nashville, Tennessee
Jonathan H. Soslow, MD, MSCI
Monroe Carell Jr. Children’s Hospital at Vanderbilt, Thomas P. Graham Division of Pediatric Cardiology, Department of Pediatrics, Nashville, Tennessee
Cassandra Hennessy, MS
Vanderbilt University Medical Center, Department of Biostatistics, Nashville, Tennessee
Richa Gupta, MD, MPH
MedStar Health, Division of Cardiology, Washington, D.C.
JoAnn Lindenfeld, MD
Vanderbilt University Medical Center, Division of Cardiovascular Medicine, Department of Internal Medicine, Nashville, Tennessee
Jeffrey M. Dendy, MD
Vanderbilt University Medical Center, Division of Cardiovascular Medicine, Department of Internal Medicine, Nashville, Tennessee
Dandan Liu, PhD
Vanderbilt University Medical Center, Department of Biostatistics, Nashville, Tennessee
Kelly H. Schlendorf, MD, MHS
Vanderbilt University Medical Center, Division of Cardiovascular Medicine, Department of Internal Medicine, Nashville, Tennessee
Daniel E. Clark, MD, MPH
Stanford University, Division of Cardiovascular Medicine, Department of Internal Medicine, Stanford, California
Sean G. Hughes, MD
Vanderbilt University Medical Center, Division of Cardiovascular Medicine, Department of Internal Medicine, Nashville, Tennessee
Hepatitis C virus positive (HCV+) organ donors offer a viable strategy for expansion of the heart donor pool without an increased risk of recipient mortality. Cardiac magnetic resonance imaging (CMR) is an effective tool for graft surveillance in heart transplant (HT) recipients. However, there are no data comparing CMR findings in HT recipients based on donor HCV status. The aim of this propensity score matched case-control study was to evaluate baseline CMR characteristics of HCV+ HT recipients and HCV- HT recipients, as well as compare cardiac allograft structure, function, performance, and tissue characterization between groups. CMR normative values did not differ between groups in matched analysis. There were no significant differences in CMR-derived biventricular function, strain, late gadolinium enhancement, or myocardial tissue characteristics by parametric mapping. This study suggests CMR can be a valuable tool for surveillance in HCV+ HT patients, and abnormalities on imaging should not be attributed to HCV infection.
