Nature Communications (Apr 2022)
Neuropathology and virus in brain of SARS-CoV-2 infected non-human primates
- Ibolya Rutkai,
- Meredith G. Mayer,
- Linh M. Hellmers,
- Bo Ning,
- Zhen Huang,
- Christopher J. Monjure,
- Carol Coyne,
- Rachel Silvestri,
- Nadia Golden,
- Krystle Hensley,
- Kristin Chandler,
- Gabrielle Lehmicke,
- Gregory J. Bix,
- Nicholas J. Maness,
- Kasi Russell-Lodrigue,
- Tony Y. Hu,
- Chad J. Roy,
- Robert V. Blair,
- Rudolf Bohm,
- Lara A. Doyle-Meyers,
- Jay Rappaport,
- Tracy Fischer
Affiliations
- Ibolya Rutkai
- Department of Pharmacology, Tulane University School of Medicine
- Meredith G. Mayer
- Tulane National Primate Research Center
- Linh M. Hellmers
- Tulane National Primate Research Center
- Bo Ning
- Department of Biochemistry and Molecular Biology, Center for Cellular and Molecular Diagnostics, Tulane University School of Medicine
- Zhen Huang
- Department of Biochemistry and Molecular Biology, Center for Cellular and Molecular Diagnostics, Tulane University School of Medicine
- Christopher J. Monjure
- Tulane National Primate Research Center
- Carol Coyne
- Tulane National Primate Research Center
- Rachel Silvestri
- Tulane National Primate Research Center
- Nadia Golden
- Tulane National Primate Research Center
- Krystle Hensley
- Tulane National Primate Research Center
- Kristin Chandler
- Tulane National Primate Research Center
- Gabrielle Lehmicke
- Tulane National Primate Research Center
- Gregory J. Bix
- Department of Neurosurgery, Clinical Neuroscience Research Center, Tulane University School of Medicine
- Nicholas J. Maness
- Tulane National Primate Research Center
- Kasi Russell-Lodrigue
- Tulane National Primate Research Center
- Tony Y. Hu
- Department of Biochemistry and Molecular Biology, Center for Cellular and Molecular Diagnostics, Tulane University School of Medicine
- Chad J. Roy
- Tulane National Primate Research Center
- Robert V. Blair
- Tulane National Primate Research Center
- Rudolf Bohm
- Tulane National Primate Research Center
- Lara A. Doyle-Meyers
- Tulane National Primate Research Center
- Jay Rappaport
- Tulane National Primate Research Center
- Tracy Fischer
- Tulane National Primate Research Center
- DOI
- https://doi.org/10.1038/s41467-022-29440-z
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 13
Abstract
COVID-19 can result in neurological manifestations and animal models could provide insights into the mechanisms. Here, the authors describe neuroinflammation, microhemorrhages and brain hypoxia in SARS-CoV-2 infected non-human primates, including in animals that don’t develop severe respiratory disease.
