Influence of allogeneic mesenchymal stem cells on leukemic cells <i>in vitro</i> sensitivity to antileukemic drugs

Abstract

In present study influence of allogeneic bone marrow mesenchymal stem cells (MSC) on patients’ leukemic cells is investigated. Influence on in vitro sensitivity to antileukemic drugs and spontaneous and cytarabine-induced apoptosis of leukemic cells was studied. It has`been shown that MSC reduce myeloid leukemic cells sensitivity to daunorubicine. However, MSC did not statistically significant influence on spontaneous and cytarabine-induced apoptosis of leukemic cells.

Keywords

• mesenchymal stem cells
• antileukemic drug sensitivity
• leukemic cells
• spontaneous apoptosis
• cytarabine-induced apoptosis