Nature Communications (Dec 2021)
Delayed induction of type I and III interferons mediates nasal epithelial cell permissiveness to SARS-CoV-2
- Catherine F. Hatton,
- Rachel A. Botting,
- Maria Emilia Dueñas,
- Iram J. Haq,
- Bernard Verdon,
- Benjamin J. Thompson,
- Jarmila Stremenova Spegarova,
- Florian Gothe,
- Emily Stephenson,
- Aaron I. Gardner,
- Sandra Murphy,
- Jonathan Scott,
- James P. Garnett,
- Sean Carrie,
- Jason Powell,
- C. M. Anjam Khan,
- Lei Huang,
- Rafiqul Hussain,
- Jonathan Coxhead,
- Tracey Davey,
- A. John Simpson,
- Muzlifah Haniffa,
- Sophie Hambleton,
- Malcolm Brodlie,
- Chris Ward,
- Matthias Trost,
- Gary Reynolds,
- Christopher J. A. Duncan
Affiliations
- Catherine F. Hatton
- Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University
- Rachel A. Botting
- Biosciences Institute, Newcastle University
- Maria Emilia Dueñas
- Biosciences Institute, Newcastle University
- Iram J. Haq
- Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University
- Bernard Verdon
- Biosciences Institute, Newcastle University
- Benjamin J. Thompson
- Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University
- Jarmila Stremenova Spegarova
- Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University
- Florian Gothe
- Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University
- Emily Stephenson
- Biosciences Institute, Newcastle University
- Aaron I. Gardner
- Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University
- Sandra Murphy
- Biosciences Institute, Newcastle University
- Jonathan Scott
- Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University
- James P. Garnett
- Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University
- Sean Carrie
- Population Health Sciences Institute, Newcastle University
- Jason Powell
- Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University
- C. M. Anjam Khan
- Biosciences Institute, Newcastle University
- Lei Huang
- Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University
- Rafiqul Hussain
- Genomics Core Facility, Biosciences Institute, Newcastle University
- Jonathan Coxhead
- Genomics Core Facility, Biosciences Institute, Newcastle University
- Tracey Davey
- Electron Microscopy Research Services, Newcastle University
- A. John Simpson
- Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University
- Muzlifah Haniffa
- Biosciences Institute, Newcastle University
- Sophie Hambleton
- Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University
- Malcolm Brodlie
- Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University
- Chris Ward
- Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University
- Matthias Trost
- Biosciences Institute, Newcastle University
- Gary Reynolds
- Biosciences Institute, Newcastle University
- Christopher J. A. Duncan
- Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University
- DOI
- https://doi.org/10.1038/s41467-021-27318-0
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 17
Abstract
The innate immune response in epithelial cells after SARS-CoV-2 infection is not fully understood. Here the authors use human air-liquid interface culture and show single cell transcription changes and delayed type I Interferon responses after SARS-CoV-2 infection compared with other respiratory viruses.
