Nature Communications (Jan 2021)
An integrative multiomic network model links lipid metabolism to glucose regulation in coronary artery disease
- Ariella T. Cohain,
- William T. Barrington,
- Daniel M. Jordan,
- Noam D. Beckmann,
- Carmen A. Argmann,
- Sander M. Houten,
- Alexander W. Charney,
- Raili Ermel,
- Katyayani Sukhavasi,
- Oscar Franzen,
- Simon Koplev,
- Carl Whatling,
- Gillian M. Belbin,
- Jialiang Yang,
- Ke Hao,
- Eimear E. Kenny,
- Zhidong Tu,
- Jun Zhu,
- Li-Ming Gan,
- Ron Do,
- Chiara Giannarelli,
- Jason C. Kovacic,
- Arno Ruusalepp,
- Aldons J. Lusis,
- Johan L. M. Bjorkegren,
- Eric E. Schadt
Affiliations
- Ariella T. Cohain
- Department of Genetics and Genomic Science and Institute for Multiscale Biology, Icahn School of Medicine at Mount Sinai
- William T. Barrington
- Department of Human Genetics/Medicine, David Geffen School of Medicine, University of California Los Angeles (UCLA)
- Daniel M. Jordan
- Department of Genetics and Genomic Science and Institute for Multiscale Biology, Icahn School of Medicine at Mount Sinai
- Noam D. Beckmann
- Department of Genetics and Genomic Science and Institute for Multiscale Biology, Icahn School of Medicine at Mount Sinai
- Carmen A. Argmann
- Department of Genetics and Genomic Science and Institute for Multiscale Biology, Icahn School of Medicine at Mount Sinai
- Sander M. Houten
- Department of Genetics and Genomic Science and Institute for Multiscale Biology, Icahn School of Medicine at Mount Sinai
- Alexander W. Charney
- Department of Genetics and Genomic Science and Institute for Multiscale Biology, Icahn School of Medicine at Mount Sinai
- Raili Ermel
- Department of Cardiac Surgery, Tartu University Hospital
- Katyayani Sukhavasi
- Department of Cardiac Surgery, Tartu University Hospital
- Oscar Franzen
- Integrated Cardio Metabolic Centre, Department of Medicine, Karolinska Institutet, Karolinska Universitetssjukhuset
- Simon Koplev
- Department of Genetics and Genomic Science and Institute for Multiscale Biology, Icahn School of Medicine at Mount Sinai
- Carl Whatling
- Translational Science, Cardiovascular, Renal and Metabolism, IMED Biotech Unit, AstraZeneca
- Gillian M. Belbin
- Department of Genetics and Genomic Science and Institute for Multiscale Biology, Icahn School of Medicine at Mount Sinai
- Jialiang Yang
- Department of Genetics and Genomic Science and Institute for Multiscale Biology, Icahn School of Medicine at Mount Sinai
- Ke Hao
- Department of Genetics and Genomic Science and Institute for Multiscale Biology, Icahn School of Medicine at Mount Sinai
- Eimear E. Kenny
- Department of Genetics and Genomic Science and Institute for Multiscale Biology, Icahn School of Medicine at Mount Sinai
- Zhidong Tu
- Department of Genetics and Genomic Science and Institute for Multiscale Biology, Icahn School of Medicine at Mount Sinai
- Jun Zhu
- Department of Genetics and Genomic Science and Institute for Multiscale Biology, Icahn School of Medicine at Mount Sinai
- Li-Ming Gan
- Early Clinical Development, Cardiovascular, Renal and Metabolism, IMED Biotech Unit, AstraZeneca
- Ron Do
- Department of Genetics and Genomic Science and Institute for Multiscale Biology, Icahn School of Medicine at Mount Sinai
- Chiara Giannarelli
- Department of Genetics and Genomic Science and Institute for Multiscale Biology, Icahn School of Medicine at Mount Sinai
- Jason C. Kovacic
- Cardiovascular Research Centre, Icahn School of Medicine at Mount Sinai
- Arno Ruusalepp
- Department of Cardiac Surgery, Tartu University Hospital
- Aldons J. Lusis
- Department of Human Genetics/Medicine, David Geffen School of Medicine, University of California Los Angeles (UCLA)
- Johan L. M. Bjorkegren
- Department of Genetics and Genomic Science and Institute for Multiscale Biology, Icahn School of Medicine at Mount Sinai
- Eric E. Schadt
- Department of Genetics and Genomic Science and Institute for Multiscale Biology, Icahn School of Medicine at Mount Sinai
- DOI
- https://doi.org/10.1038/s41467-020-20750-8
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 13
Abstract
Some cholesterol-lowering drugs can increase the risk of type 2 diabetes, but the mechanism behind this is not fully understood. Here the authors show that there is a single genetic regulatory module that influences both cholesterol levels and glucose levels, providing a link between cholesterol levels and diabetes.
