K2S2O8-Promoted Aryl Thioamides Synthesis from Aryl Aldehydes Using Thiourea as the Sulfur Source

Yongjun Bian; Xingyu Qu; Yongqiang Chen; Jun Li; Leng Liu

doi:10.3390/molecules23092225

Molecules (Sep 2018)

K2S2O8-Promoted Aryl Thioamides Synthesis from Aryl Aldehydes Using Thiourea as the Sulfur Source

Yongjun Bian,
Xingyu Qu,
Yongqiang Chen,
Jun Li,
Leng Liu

Affiliations

Yongjun Bian: College of Chemistry and Chemical Engineering, Jinzhong University, Yuci 030619, China
Xingyu Qu: College of Chemistry and Chemical Engineering, Jinzhong University, Yuci 030619, China
Yongqiang Chen: College of Chemistry and Chemical Engineering, Jinzhong University, Yuci 030619, China
Jun Li: College of Chemistry and Chemical Engineering, Jinzhong University, Yuci 030619, China
Leng Liu: College of Chemistry and Chemical Engineering, Jinzhong University, Yuci 030619, China

DOI: https://doi.org/10.3390/molecules23092225
Journal volume & issue: Vol. 23, no. 9
p. 2225

Abstract

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Thiourea as a sulfur atom transfer reagent was applied for the synthesis of aryl thioamides through a three-component coupling reaction with aryl aldehydes and N,N-dimethylformamide (DMF) or N,N-dimethylacetamide (DMAC). The reaction could tolerate various functional groups and gave moderate to good yields of desired products under the transition-metal-free condition.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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