mSystems (Aug 2021)

Embracing Metagenomic Complexity with a Genome-Free Approach

  • Izaak Coleman,
  • Tal Korem

DOI
https://doi.org/10.1128/mSystems.00816-21
Journal volume & issue
Vol. 6, no. 4

Abstract

Read online

A central paradigm in microbiome data analysis, which we term the genome-centric paradigm, is that a linear (nonbranching) DNA sequence is the ideal representation of a microbial genome. This representation is natural, as microbes indeed have nonbranching genomes.