Pericytes regulate VEGF-induced endothelial sprouting through VEGFR1

Hanna M. Eilken; Rodrigo Diéguez-Hurtado; Inga Schmidt; Masanori Nakayama; Hyun-Woo Jeong; Hendrik Arf; Susanne Adams; Napoleone Ferrara; Ralf H. Adams

doi:10.1038/s41467-017-01738-3

Nature Communications (Nov 2017)

Pericytes regulate VEGF-induced endothelial sprouting through VEGFR1

Hanna M. Eilken,
Rodrigo Diéguez-Hurtado,
Inga Schmidt,
Masanori Nakayama,
Hyun-Woo Jeong,
Hendrik Arf,
Susanne Adams,
Napoleone Ferrara,
Ralf H. Adams

Affiliations

Hanna M. Eilken: Max Planck Institute for Molecular Biomedicine, Department of Tissue Morphogenesis and University of Münster, Faculty of Medicine
Rodrigo Diéguez-Hurtado: Max Planck Institute for Molecular Biomedicine, Department of Tissue Morphogenesis and University of Münster, Faculty of Medicine
Inga Schmidt: Max Planck Institute for Molecular Biomedicine, Department of Tissue Morphogenesis and University of Münster, Faculty of Medicine
Masanori Nakayama: Max Planck Institute for Molecular Biomedicine, Department of Tissue Morphogenesis and University of Münster, Faculty of Medicine
Hyun-Woo Jeong: Max Planck Institute for Molecular Biomedicine, Department of Tissue Morphogenesis and University of Münster, Faculty of Medicine
Hendrik Arf: Max Planck Institute for Molecular Biomedicine, Department of Tissue Morphogenesis and University of Münster, Faculty of Medicine
Susanne Adams: Max Planck Institute for Molecular Biomedicine, Department of Tissue Morphogenesis and University of Münster, Faculty of Medicine
Napoleone Ferrara: University of California San Diego Medical Center
Ralf H. Adams: Max Planck Institute for Molecular Biomedicine, Department of Tissue Morphogenesis and University of Münster, Faculty of Medicine

DOI: https://doi.org/10.1038/s41467-017-01738-3
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 14

Abstract

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Pericytes are essential for the development, maintenance and function of vascular networks. Here, Eilken and colleagues show that expression of the decoy receptor VEGFR1 by pericytes spatially restricts VEGF signalling, thus regulating VEGF-induced endothelial cell sprouting in developing tissues.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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