Role of the intestinal MALT in pathogenesis of the IgA-nephropathy

Abstract

Modern view on pathogenesis of immunoglobulin (Ig)A-nephropathy and possible relation to intestinal MALT-system activity is presented in the article. Aberrant glycosylation of IgA and increased association of IgA-nephropathy with intestinal diseases or abnormal intestinal permeability are discussed in details. Based on supposed entero-renal pathogenesis of the disease future treatment modalities are considered. Relevant worlds literature is cited.

Keywords

• immunoglobulin a-nephropathy
• immunoglobulin a
• аberrant glycosylation of immunoglobulin a
• intestinal permeability
• malt