Терапевтический архив (Jul 2015)

The specific features of diagnosis of mixed-phenotype acute leukemia: A combination of B-cell antigen expressions according to the results of flow cytometry and morphological markers of myeloid differentiation in blast cells: A clinical case

  • S V Gritsaev,
  • I I Kostroma,
  • G M Ryadnova,
  • S A Tiranova,
  • Zh V Chubukina,
  • V A Balashova,
  • M N Zenina,
  • I S Martynkevich,
  • N A Potikhonova,
  • K M Abdulkadyrov

Journal volume & issue
Vol. 87, no. 7
pp. 97 – 100

Abstract

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This rare type of acute leukemia, blast cells of which express myeloid and/or lymphoid markers, is mainly diagnosed using flow cytometric findings. The paper describes a clinical case of mixed-phenotype acute leukemia, in which B-cell lymphoid antigen expressions were revealed by a flow cytometric technique, while bone marrow morphological specimens showed the signs of myeloid differentiation specific to blast cells. It is concluded that there is a need for a comprehensive examination of patients with new-onset acute leukemia and for an aggregate analysis of flow cytometric results with morphological and cytochemical findings.

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