Modern tools for the functionalization of C(sp3) centers by catalysis

Abstract

In the quest for molecular complexity, the direct and selective functionalization of C(sp3) centers is of paramount importance. As sulfur- and/or fluorine-containing molecules are particularly important, the development of methods to (regio)selectively introduce moieties containing these atoms on a C(sp3) center by direct C–H bond functionalization or decarboxylative reaction has garnered our interest in the last few years. Given the challenges that the direct functionalization of C(sp3) centers represents, this account summarizes our recent contributions thanks to strategies based on transition metal catalysis and photochemistry.

Keywords

• Synthetic methodology
• C(sp³) centers
• Transition metal catalysis
• Photochemical transformations
• Proximal and distal functionalization