Nature Communications (Jun 2018)
Intraamniotic Zika virus inoculation of pregnant rhesus macaques produces fetal neurologic disease
- Lark L. Coffey,
- Rebekah I. Keesler,
- Patricia A. Pesavento,
- Kevin Woolard,
- Anil Singapuri,
- Jennifer Watanabe,
- Christina Cruzen,
- Kari L. Christe,
- Jodie Usachenko,
- JoAnn Yee,
- Victoria A. Heng,
- Eliza Bliss-Moreau,
- J. Rachel Reader,
- Wilhelm von Morgenland,
- Anne M. Gibbons,
- Kenneth Jackson,
- Amir Ardeshir,
- Holly Heimsath,
- Sallie Permar,
- Paranthaman Senthamaraikannan,
- Pietro Presicce,
- Suhas G. Kallapur,
- Jeffrey M. Linnen,
- Kui Gao,
- Robert Orr,
- Tracy MacGill,
- Michelle McClure,
- Richard McFarland,
- John H. Morrison,
- Koen K. A. Van Rompay
Affiliations
- Lark L. Coffey
- Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California
- Rebekah I. Keesler
- California National Primate Research Center, University of California
- Patricia A. Pesavento
- Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California
- Kevin Woolard
- Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California
- Anil Singapuri
- Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California
- Jennifer Watanabe
- California National Primate Research Center, University of California
- Christina Cruzen
- California National Primate Research Center, University of California
- Kari L. Christe
- California National Primate Research Center, University of California
- Jodie Usachenko
- California National Primate Research Center, University of California
- JoAnn Yee
- California National Primate Research Center, University of California
- Victoria A. Heng
- California National Primate Research Center, University of California
- Eliza Bliss-Moreau
- California National Primate Research Center, University of California
- J. Rachel Reader
- California National Primate Research Center, University of California
- Wilhelm von Morgenland
- California National Primate Research Center, University of California
- Anne M. Gibbons
- California National Primate Research Center, University of California
- Kenneth Jackson
- Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California
- Amir Ardeshir
- California National Primate Research Center, University of California
- Holly Heimsath
- Duke Human Vaccine Institute, Duke University Medical Center
- Sallie Permar
- Duke Human Vaccine Institute, Duke University Medical Center
- Paranthaman Senthamaraikannan
- Division of Neonatology and Pulmonary Biology, Cincinnati Children’s Hospital Research Foundation
- Pietro Presicce
- Divisions of Neonatology and Developmental Biology, David Geffen School of Medicine at the University of California
- Suhas G. Kallapur
- Divisions of Neonatology and Developmental Biology, David Geffen School of Medicine at the University of California
- Jeffrey M. Linnen
- Grifols Diagnostic Solutions, Inc.
- Kui Gao
- Grifols Diagnostic Solutions, Inc.
- Robert Orr
- Office of Counterterrorism and Emerging Threats, Office of the Chief Scientist, Food and Drug Administration
- Tracy MacGill
- Office of Counterterrorism and Emerging Threats, Office of the Chief Scientist, Food and Drug Administration
- Michelle McClure
- Office of Tissues and Advanced Therapies, Center for Biologics Evaluation and Research, Food and Drug Administration
- Richard McFarland
- The Advanced Regenerative Manufacturing Institute
- John H. Morrison
- California National Primate Research Center, University of California
- Koen K. A. Van Rompay
- California National Primate Research Center, University of California
- DOI
- https://doi.org/10.1038/s41467-018-04777-6
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 12
Abstract
Zika virus infection of pregnant women can cause congenital brain defects. Here, Coffey et al. establish a pregnant rhesus macaque model, using intravenous and intraamniotic route of infection, that reliably reproduces fetal neurologic defects of congenital Zika syndrome in humans.
