Turkderm Turkish Archives of Dermatology and Venereology (Mar 2021)

Granulomatous skin infections

  • Didem Dinçer Rota,
  • Mehmet Can Emeksiz

DOI
https://doi.org/10.4274/turkderm.galenos.2020.16362
Journal volume & issue
Vol. 55, no. 1
pp. 1 – 8

Abstract

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Granulomatous skin disorders are a heterogeneous group of disorders characterized by granuloma formation on histopathology. They may be triggered by various stimuli, including infectious and non-infectious stimuli (foreign bodies, malignancy, metabolites, and chemicals), of different etiological origins. Although pathophysiological mechanisms are still poorly understood, infectious granuloma formation may occur if the patient’s immune system could not eliminate an agent. Clinically, localized or disseminated infectious granuloma formation can be related to the infectious agent’s pathogenicity or the patient’s immunity. Typical infectious agents causing infectious granulomatous reactions are mycobacteria, fungal infections, or parasites, such as leishmaniasis. This review aims to summarize granulomatous skin diseases encountered more frequently in our clinical experience because of infectious causes.

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