A Multiple Synergic Treatment for Non-Healing Ulcer Management in a Patient with <i>Klippel–Trenaunay</i> Syndrome
Cristina Vocca,
Gianmarco Marcianò,
Vincenzo Rania,
Luca Catarisano,
Caterina Palleria,
Salvatore Ciranni,
Giuseppina Torcia,
Raffaele Serra,
Francesco Monea,
Giuseppe Spaziano,
Giovambattista De Sarro,
Rita Citraro,
Luca Gallelli
Affiliations
Cristina Vocca
Operative Unit of Pharmacology and Pharmacovigilance, “Renato Dulbecco University Hospital”, Department of Health Science, University Magna Graecia, 88100 Catanzaro, Italy
Gianmarco Marcianò
Operative Unit of Pharmacology and Pharmacovigilance, “Renato Dulbecco University Hospital”, Department of Health Science, University Magna Graecia, 88100 Catanzaro, Italy
Vincenzo Rania
Operative Unit of Pharmacology and Pharmacovigilance, “Renato Dulbecco University Hospital”, Department of Health Science, University Magna Graecia, 88100 Catanzaro, Italy
Luca Catarisano
Operative Unit of Pharmacology and Pharmacovigilance, “Renato Dulbecco University Hospital”, Department of Health Science, University Magna Graecia, 88100 Catanzaro, Italy
Caterina Palleria
Operative Unit of Pharmacology and Pharmacovigilance, “Renato Dulbecco University Hospital”, Department of Health Science, University Magna Graecia, 88100 Catanzaro, Italy
Salvatore Ciranni
Vascular Surgery Unit, Department of Medical and Surgical Science, University Magna Graecia, 88100 Catanzaro, Italy
Giuseppina Torcia
Vascular Surgery Unit, Department of Medical and Surgical Science, University Magna Graecia, 88100 Catanzaro, Italy
Raffaele Serra
Vascular Surgery Unit, Department of Medical and Surgical Science, University Magna Graecia, 88100 Catanzaro, Italy
Francesco Monea
Research Center FAS@UMG, Department of Health Science, University Magna Graecia, 88100 Catanzaro, Italy
Giuseppe Spaziano
Department of Environmental Biological and Pharmaceutical Sciences and Technologies, University of Campania “Luigi Vanvitelli”, 81100 Caserta, Italy
Giovambattista De Sarro
Operative Unit of Pharmacology and Pharmacovigilance, “Renato Dulbecco University Hospital”, Department of Health Science, University Magna Graecia, 88100 Catanzaro, Italy
Rita Citraro
Operative Unit of Pharmacology and Pharmacovigilance, “Renato Dulbecco University Hospital”, Department of Health Science, University Magna Graecia, 88100 Catanzaro, Italy
Luca Gallelli
Operative Unit of Pharmacology and Pharmacovigilance, “Renato Dulbecco University Hospital”, Department of Health Science, University Magna Graecia, 88100 Catanzaro, Italy
Klippel–Trenanauy syndrome (KTS) is a rare genetic disease determined by overexpression of the phosphatidylinositol-4-5-bisphosphate 3 kinase catalytic subunit (PIK3CA) gene. The clinical presentation is characterized by venous and capillary malformations and lymphatic malformation. To date, no definitive treatment has been suggested in order to improve the clinical symptoms related to the developments of a skin wound. In this case, we describe a young man with KTS that developed a severe skin wound in the lower right limb unresponsive to the common treatment but responsive to a treatment with oxygen-ozone therapy, pulsed magnetic fields (diamagnetic treatment), and topical fixed association of cocum caprylate, oleic acid, quercetin, and 18-β glycyrrhetinic acid. This is the first case that supports a multistep approach to treat a rare and severe disease, and we hope that other studies can support our data.
