Nature Communications (Jun 2020)

Harmonization of quality metrics and power calculation in multi-omic studies

  • Sonia Tarazona,
  • Leandro Balzano-Nogueira,
  • David Gómez-Cabrero,
  • Andreas Schmidt,
  • Axel Imhof,
  • Thomas Hankemeier,
  • Jesper Tegnér,
  • Johan A. Westerhuis,
  • Ana Conesa

DOI
https://doi.org/10.1038/s41467-020-16937-8
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 13

Abstract

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Multi-omics studies are popular but lack rigorous criteria for experimental design. We define Figures of Merit across omics to comparatively describe their performance, and present new algorithms for sample size calculation in multi-omics experiments aiming either at feature selection or sample classification.