Nature Communications (May 2021)

A trimethoprim derivative impedes antibiotic resistance evolution

  • Madhu Sudan Manna,
  • Yusuf Talha Tamer,
  • Ilona Gaszek,
  • Nicole Poulides,
  • Ayesha Ahmed,
  • Xiaoyu Wang,
  • Furkan C. R. Toprak,
  • DaNae R. Woodard,
  • Andrew Y. Koh,
  • Noelle S. Williams,
  • Dominika Borek,
  • Ali Rana Atilgan,
  • John D. Hulleman,
  • Canan Atilgan,
  • Uttam Tambar,
  • Erdal Toprak

DOI
https://doi.org/10.1038/s41467-021-23191-z
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 10

Abstract

Read online

The efficacy of the antibiotic trimethoprim, which inhibits bacterial dihydrofolate reductase (DHFR), is limited by the rapid emergence of resistant bacteria. Here, Manna et al. show that 4’-desmethyltrimethoprim inhibits DHFR and a common TMP-resistant variant, and impedes evolution of antibiotic resistance by selecting against the emergence of this variant.