Revista Brasileira de Ginecologia e Obstetrícia (Dec 2017)

Is Pethidine Safe during Labor? Systematic Review

  • Rogevando Rodrigues Nunes,
  • Paulo Giordano Baima Colares,
  • Juliana Pinto Montenegro

DOI
https://doi.org/10.1055/s-0037-1604065
Journal volume & issue
Vol. 39, no. 12
pp. 686 – 691

Abstract

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Abstract Purpose To verify if pethidine is safe for the conceptus when used during labor. Methods Systematic review in the Capes Periodicals/PubMed and MEDLINE/Virtual Health Library (BVS, in the Portuguese acronym) databases. Results A total of 17 studies published from January 1st, 2000, to September 2nd, 2016, with a total of 1,688 participants involved were included in the present review. There was no record of conceptus vitality decrease associated with low doses of pethidine being administered to mothers during labor. Conclusions Intramuscular (IM) or intravenous (IV) pethidine at low doses, of up to 50 mg, is safe to administer during labor.

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