An Overview of the Chemical Characteristics, Bioactivity and Achievements Regarding the Therapeutic Usage of Acetogenins from <i>Annona cherimola</i> Mill.
Alexandra G. Durán,
M. Teresa Gutiérrez,
Francisco J. R. Mejías,
José M. G. Molinillo,
Francisco A. Macías
Affiliations
Alexandra G. Durán
Allelopathy Group, Department of Organic Chemistry, Institute of Biomolecules (INBIO), Campus de Excelencia Internacional (ceiA3), School of Science, University of Cadiz, C/República Saharaui, 7, Puerto Real, 11510 Cadiz, Spain
M. Teresa Gutiérrez
Allelopathy Group, Department of Organic Chemistry, Institute of Biomolecules (INBIO), Campus de Excelencia Internacional (ceiA3), School of Science, University of Cadiz, C/República Saharaui, 7, Puerto Real, 11510 Cadiz, Spain
Francisco J. R. Mejías
Allelopathy Group, Department of Organic Chemistry, Institute of Biomolecules (INBIO), Campus de Excelencia Internacional (ceiA3), School of Science, University of Cadiz, C/República Saharaui, 7, Puerto Real, 11510 Cadiz, Spain
José M. G. Molinillo
Allelopathy Group, Department of Organic Chemistry, Institute of Biomolecules (INBIO), Campus de Excelencia Internacional (ceiA3), School of Science, University of Cadiz, C/República Saharaui, 7, Puerto Real, 11510 Cadiz, Spain
Francisco A. Macías
Allelopathy Group, Department of Organic Chemistry, Institute of Biomolecules (INBIO), Campus de Excelencia Internacional (ceiA3), School of Science, University of Cadiz, C/República Saharaui, 7, Puerto Real, 11510 Cadiz, Spain
Annona cherimola Mill., or the custard apple, is one of the species belonging to the Annonaceae family, is widely used in traditional medicine, and has been reported to be a valuable source of bioactive compounds. A unique class of secondary metabolites derived from this family are Annonaceous acetogenins, lipophilic polyketides considered to be amongst the most potent antitumor compounds. This review provides an overview of the chemical diversity, isolation procedures, bioactivity, modes of application and synthetic derivatives of acetogenins from A. cherimola Mill.
