Nature Communications (Sep 2021)
Accelerated functional brain aging in pre-clinical familial Alzheimer’s disease
- Julie Gonneaud,
- Alex T. Baria,
- Alexa Pichet Binette,
- Brian A. Gordon,
- Jasmeer P. Chhatwal,
- Carlos Cruchaga,
- Mathias Jucker,
- Johannes Levin,
- Stephen Salloway,
- Martin Farlow,
- Serge Gauthier,
- Tammie L. S. Benzinger,
- John C. Morris,
- Randall J. Bateman,
- John C. S. Breitner,
- Judes Poirier,
- Etienne Vachon-Presseau,
- Sylvia Villeneuve,
- Alzheimer’s Disease Neuroimaging Initiative (ADNI),
- Dominantly Inherited Alzheimer Network (DIAN) Study Group,
- Pre-symptomatic Evaluation of Experimental or Novel Treatments for Alzheimer’s Disease (PREVENT-AD) Research Group
Affiliations
- Julie Gonneaud
- Douglas Mental Health University Institute, McGill University
- Alex T. Baria
- Douglas Mental Health University Institute, McGill University
- Alexa Pichet Binette
- Douglas Mental Health University Institute, McGill University
- Brian A. Gordon
- Knight Alzheimer Disease Research Center, Washington University School of Medicine
- Jasmeer P. Chhatwal
- Brigham and Women’s Hospital–Massachusetts General Hospital
- Carlos Cruchaga
- Knight Alzheimer Disease Research Center, Washington University School of Medicine
- Mathias Jucker
- Hertie-Institute for Clinical Brain Research, University of Tübingen
- Johannes Levin
- Ludwig-Maximilians-Universität München, German Center for Neurodegenerative Diseases and Munich Cluster for Systems Neurology (SyNergy)
- Stephen Salloway
- Butler Hospital
- Martin Farlow
- Department of Neurology, Indiana University School of Medicine
- Serge Gauthier
- Douglas Mental Health University Institute, McGill University
- Tammie L. S. Benzinger
- Knight Alzheimer Disease Research Center, Washington University School of Medicine
- John C. Morris
- Knight Alzheimer Disease Research Center, Washington University School of Medicine
- Randall J. Bateman
- Knight Alzheimer Disease Research Center, Washington University School of Medicine
- John C. S. Breitner
- Douglas Mental Health University Institute, McGill University
- Judes Poirier
- Douglas Mental Health University Institute, McGill University
- Etienne Vachon-Presseau
- Department of Anesthesia, Faculty of Medicine, McGill University
- Sylvia Villeneuve
- Douglas Mental Health University Institute, McGill University
- Alzheimer’s Disease Neuroimaging Initiative (ADNI)
- Dominantly Inherited Alzheimer Network (DIAN) Study Group
- Pre-symptomatic Evaluation of Experimental or Novel Treatments for Alzheimer’s Disease (PREVENT-AD) Research Group
- DOI
- https://doi.org/10.1038/s41467-021-25492-9
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 17
Abstract
Alzheimer’s disease has been associated with increased structural brain aging. Here the authors describe a model that predicts brain aging from resting state functional connectivity data, and demonstrate this is accelerated in individuals with pre-clinical familial Alzheimer’s disease.
