Mandibular Osteonecrosis Associated with Antacid Therapy (Esomeprazole)

Abstract

Introduction: Osteonecrosis of the jaw has been consistently reported in the literature associated to the high-dose intravenous bisphosphonate therapy. However, osteonecrosis can also occur in patients who have other risk factors. Case description: An unusual case of ONJ in a patient being treated with esomeprazole is reported. Discussion: The probable association between proton pump inhibitor intake and osteonecrosis of the jaw should alert clinicians. Collaborations between medical and dental doctor and an early diagnosis might prevent or reduce the morbidity resulting from advanced destructive lesions of the jaw bone.

Keywords

• mandibular osteonecrosis
• antacid therapy
• esomeprazole
• osteonecrosis of the jaw
• proton pump inhibitors