Evolution of anti-SARS-CoV-2 spike protein titers after two-dose of COVID-19 vaccination among people living with HIV

Wang-Da Liu; Man Wai Pang; Jann-Tay Wang; Hsin-Yun Sun; Yu-Shan Huang; Kuan-Yin Lin; Un-In Wu; Guei-Chi Li; Wen-Chun Liu; Yi-Ching Su; Pu-Chi He; Chia-Yi Lin; Chih-Yu Yeh; Yu-Chen Cheng; Yi Yao; Yi-Ting Chen; Pei-Ying Wu; Ling-Ya Chen; Yu-Zhen Luo; Hsi-Yen Chang; Wang-Huei Sheng; Szu-Min Hsieh; Sui-Yuan Chang; Chien-Ching Hung; Shan-Chwen Chang

Journal of Virus Eradication (Dec 2022)

Evolution of anti-SARS-CoV-2 spike protein titers after two-dose of COVID-19 vaccination among people living with HIV

Wang-Da Liu,
Man Wai Pang,
Jann-Tay Wang,
Hsin-Yun Sun,
Yu-Shan Huang,
Kuan-Yin Lin,
Un-In Wu,
Guei-Chi Li,
Wen-Chun Liu,
Yi-Ching Su,
Pu-Chi He,
Chia-Yi Lin,
Chih-Yu Yeh,
Yu-Chen Cheng,
Yi Yao,
Yi-Ting Chen,
Pei-Ying Wu,
Ling-Ya Chen,
Yu-Zhen Luo,
Hsi-Yen Chang,
Wang-Huei Sheng,
Szu-Min Hsieh,
Sui-Yuan Chang,
Chien-Ching Hung,
Shan-Chwen Chang

Affiliations

Wang-Da Liu: Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan; Department of Medicine, National Taiwan University Cancer Center, Taipei, Taiwan
Man Wai Pang: Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan
Jann-Tay Wang: Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan; Institute of Infectious Diseases and Vaccinology, National Health Research Institutes, Zhunan, Taiwan
Hsin-Yun Sun: Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan
Yu-Shan Huang: Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan
Kuan-Yin Lin: Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan
Un-In Wu: Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan; Department of Medicine, National Taiwan University Cancer Center, Taipei, Taiwan
Guei-Chi Li: Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan
Wen-Chun Liu: Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan
Yi-Ching Su: Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan
Pu-Chi He: Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan; Department of Medical Education, National Taiwan University, Taipei, Taiwan
Chia-Yi Lin: Department of Nursing, National Taiwan University Hospital, Taipei, Taiwan
Chih-Yu Yeh: Department of Nursing, National Taiwan University Hospital, Taipei, Taiwan
Yu-Chen Cheng: Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan
Yi Yao: Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan
Yi-Ting Chen: Center of Infection Control, National Taiwan University Hospital, Taipei, Taiwan
Pei-Ying Wu: Center of Infection Control, National Taiwan University Hospital, Taipei, Taiwan
Ling-Ya Chen: Center of Infection Control, National Taiwan University Hospital, Taipei, Taiwan
Yu-Zhen Luo: Center of Infection Control, National Taiwan University Hospital, Taipei, Taiwan
Hsi-Yen Chang: Center of Infection Control, National Taiwan University Hospital, Taipei, Taiwan
Wang-Huei Sheng: Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan; Department of Medical Education, National Taiwan University, Taipei, Taiwan; School of Medicine, National Taiwan University College of Medicine, Taipei, Taiwan
Szu-Min Hsieh: Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan
Sui-Yuan Chang: Department of Clinical Laboratory Sciences and Medical Biotechnology, College of Medicine, National Taiwan University, Taipei, Taiwan; Department of Laboratory Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan; Corresponding author. Department of Laboratory Medicine, National Taiwan University Hospital, 7 Chung-Shan South Rd., Taipei City, 10002, Taiwan.
Chien-Ching Hung: Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan; Department of Tropical Medicine and Parasitology, National Taiwan University College of Medicine, Taipei, Taiwan; Department of Internal Medicine, National Taiwan University Hospital Yun-Lin Branch, Yun-Lin County, Taiwan; Department of Medical Research, China Medical University Hospital, Taichung, Taiwan; China Medical University, Taichung, Taiwan; Corresponding author. Department of Internal Medicine, National Taiwan University Hospital, 7 Chung-Shan South Rd., Taipei City, 10002, Taiwan.
Shan-Chwen Chang: Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan; School of Medicine, National Taiwan University College of Medicine, Taipei, Taiwan

Journal volume & issue: Vol. 8, no. 4
p. 100308

Abstract

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Background: A community COVID-19 outbreak caused by the B.1.1.7 SARS-CoV-2 variant occurred in Taiwan in May 2021. High-risk populations such as people living with HIV (PLWH) were recommended to receive two doses of COVID-19 vaccines. While SARS-CoV-2 vaccines have demonstrated promising results in general population, real-world information on the serological responses remains limited among PLWH. Methods: PLWH receiving the first dose of SARS-CoV-2 vaccine from 2020 to 2021 were enrolled. Determinations of anti-SARS-CoV-2 spike IgG titers were performed every one to three months, the third dose of the SARS-CoV-2 vaccine or confirmed SARS-CoV-2 infection. All serum samples were tested for anti-nucleocapsid antibody and those tested positive were excluded from analysis. Results: A total of 1189 PLWH were enrolled: 829 (69.7%) receiving two doses of the AZD1222 vaccine, 232 (19.5%) of the mRNA-1273 vaccine, and 128 (10.8%) of the BNT162b2 vaccine. At all time-points, PLWH receiving two doses of mRNA vaccines had consistently higher antibody levels than those receiving the AZD1222 vaccine (p 141 BAU/mL within 12 weeks, included type 2 diabetes mellitus (DM) (adjusted odds ratio [aOR], 2.24; 95% CI, 1.25–4), a CD4 T cell count 899 BAU/mL within 12 weeks were a CD4 T cell count <200 cells/mm3 on first-dose vaccination (aOR, 3.95; 95% CI, 1.08–14.42) and dual BNT162b2 vaccination (aOR, 4.21; 95% CI, 2.57–6.89). Conclusions: Two doses of homologous mRNA vaccination achieved significantly higher serological responses than vaccination with AZD1222 among PLWH. Those with CD4 T cell counts <200 cells/mm3 and DM had consistently lower serological responses.

Published in Journal of Virus Eradication

ISSN: 2055-6640 (Print); 2055-6659 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Science: Microbiology; Medicine: Public aspects of medicine
Website: https://www.journals.elsevier.com/journal-of-virus-eradication

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