Study of the Effects of Mogadon in Treatment of Infantile Spasms

Abstract

Among epileptic syndromes the infantile spasms ( west syndrome ) is the most malignant one and leads to irreparable brain damage, which is related directly to duration of spasms. The effectiveness of Mogadon (Nitrazepam) on treatment of infantile spasms was studied for two-years (1998-2000) at neurologic ward of Mofid children hospital , Tehran , Iran. This was prospective uncontrolled clinical trial on 30 childs age 2-24 months with infantile spasms. Patients received Mogadon (NZP) 0.5-1 mg/kg/hr in three divided dose with meal, the patients evaluated regard to complete and relative control of seizure and drug side effects at the end of 2,4 and 6 weeks of therapy. At the end of six weeks of therapy 63% were seizure free , 26% had reduced frequency of siezure , and 47% had complete normalization of tracing EEG. Because of high-effectiveness , few side effects and low cost the Mogadon (NZP) could be a drug of choice in treatment of infantile spasms.

Keywords

• epilepsy – therapy / infantile spasm/ nitrazepam