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Effect of reduced glutathione assisted therapy on immune function, antioxidant function and inflammatory factor in ovarian cancer after chemotherapy

Journal of Hainan Medical University. 2018;24(05):60-63

 

Journal Homepage

Journal Title: Journal of Hainan Medical University

ISSN: 1007-1237 (Print)

Publisher: Editorial Board of Journal of Hainan Medical University

Society/Institution: Hainan Medical University

LCC Subject Category: Medicine

Country of publisher: China

Language of fulltext: English

Full-text formats available: PDF

 

AUTHORS


Dan-Feng Gao (Department of Obstetrics and Gynecology, Shanghai Tenth People's Hospital, Shanghai 200072, China)

Jia-Jing Cheng (Department of Obstetrics and Gynecology, Shanghai Tenth People's Hospital, Shanghai 200072, China)

Li-Wen Song (Department of Obstetrics and Gynecology, Shanghai Tenth People's Hospital, Shanghai 200072, China)

EDITORIAL INFORMATION

Double blind peer review

Editorial Board

Instructions for authors

Time From Submission to Publication: 10 weeks

 

Abstract | Full Text

Objective: To investigate the effect of reduced glutathione adjuvant treatment on immune function, antioxidant function and inflammatory cytokines in ovarian cancer patients after chemotherapy. Result: A total of 100 patients with ovarian cancer who were admitted in our hospital from January 2015 to June 2017. According to the enrollment serial number, divided them into research group and control group each 50 cases, the control group was given conventional chemical drug treatment, the research group were given reduced glutathione adjuvant therapy on the basis of chemical therapy. The T lymphocyte subsets, antioxidant indexes MDA, SOD, T-AOC and inflammatory cytokines TNF-α, IL-6, IL-8 levels change in two groups before chemotherapy (T0), 1 month after chemotherapy (T1) and 3 months (T2) were observed. Result: (1) The CD3+,CD4+,CD4+/CD8+ levels at T1 was decreased than T0, and T2 was significantly increased when compared with T1, The CD8+ level at T1 was higher than T0, and the T2 was significantly decreased than T1 in both groups. The levels of the CD3+, CD4+, CD4+/CD8 at T1, T2 in the research group were higher than the control group, while the levels of CD8+ in the research group was lower than the control group. The difference was statistically significant. (2) The level of MDA at T1 was higher than T0, T2 was significantly lower than T1 in both groups. The levels of SOD and T-AOC at T1 were decreased than T0, and T2 was significantly higher than T1. The levels of SOD and T-AOC at T1, T2 in the research group were higher than in the control group, while the MDA level was lower than in the control group. The difference was statistically significant. (3) The levels of TNF-α, IL-6 and IL-8 at T1 in two groups were significantly higher than T0, and the T2 decreased significantly when compared with T1, The levels of TNF-α, IL-6 and IL-8 at T1, T2 in the research group were lower than in the control group. The difference was statistically significant. Conclusion: The reduced glutathione adjuvant chemotherapy for postoperative ovarian cancer can help to protect the body's immune function, antioxidant function and reduce inflammation factor.