Expression of Programmed Cell Death 1 and Lymphocyte Activation Gene 3 in Perioperation of Adenocarcinoma of Esophagogastric Junction and Related Significance

Abstract

Objective To evaluate the expression of programmed cell death 1 (PD-1) and lymphocyte activation gene 3 (LAG-3) in lymphocytes following surgery for advanced adenocarcinoma of esophagogastric junction(AEGJ), and to understand the effect of radical surgical trauma on cellular immune function. Methods On 102 patients with advanced AEGJ, open radical R0 resection and D2 lymph node dissection were performed. The expression level of PD-1 and LAG-3 in T cells were measured by flow cytometry. Results Compared with the control group, preoperative CD3+, CD3+CD4+ T lymphocytes were significantly decreased (P 0.05). Conclusion The surgical trauma of AEGJ may lead to the change in the proportion of CD4+ PD-1+ T cells through various cytokines, so as to regulate the proportion of T lymphocyte subpopulation and inhibit the cellular immunity.

Keywords

• adenocarcinoma of esophagogastric junction
• radical operation
• perioperative
• cellular immune