Nature Communications (Jun 2017)
DNA vaccination protects mice against Zika virus-induced damage to the testes
- Bryan D. Griffin,
- Kar Muthumani,
- Bryce M. Warner,
- Anna Majer,
- Mable Hagan,
- Jonathan Audet,
- Derek R. Stein,
- Charlene Ranadheera,
- Trina Racine,
- Marc-Antoine De La Vega,
- Jocelyne Piret,
- Stephanie Kucas,
- Kaylie N. Tran,
- Kathy L. Frost,
- Christine De Graff,
- Geoff Soule,
- Leanne Scharikow,
- Jennifer Scott,
- Gordon McTavish,
- Valerie Smid,
- Young K. Park,
- Joel N. Maslow,
- Niranjan Y. Sardesai,
- J. Joseph Kim,
- Xiao-jian Yao,
- Alexander Bello,
- Robbin Lindsay,
- Guy Boivin,
- Stephanie A. Booth,
- Darwyn Kobasa,
- Carissa Embury-Hyatt,
- David Safronetz,
- David B. Weiner,
- Gary P. Kobinger
Affiliations
- Bryan D. Griffin
- Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada
- Kar Muthumani
- The Wistar Institute
- Bryce M. Warner
- Department of Medical Microbiology and Infectious Diseases, University of Manitoba
- Anna Majer
- Molecular Pathobiology, National Microbiology Laboratory, Public Health Agency of Canada
- Mable Hagan
- Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada
- Jonathan Audet
- Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada
- Derek R. Stein
- Department of Medical Microbiology and Infectious Diseases, University of Manitoba
- Charlene Ranadheera
- Department of Medical Microbiology and Infectious Diseases, University of Manitoba
- Trina Racine
- Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada
- Marc-Antoine De La Vega
- Department of Microbiology and Immunology, Faculty of Medicine, Laval University
- Jocelyne Piret
- Research Center in Infectious Diseases of the CHU of Québec and Laval University
- Stephanie Kucas
- Zoonotic Diseases and Special Pathogens, National Microbiology Laboratory, Public Health Agency of Canada
- Kaylie N. Tran
- Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada
- Kathy L. Frost
- Molecular Pathobiology, National Microbiology Laboratory, Public Health Agency of Canada
- Christine De Graff
- Veterinary Technical Services, Public Health Agency of Canada, National Microbiology Laboratory
- Geoff Soule
- Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada
- Leanne Scharikow
- Zoonotic Diseases and Special Pathogens, National Microbiology Laboratory, Public Health Agency of Canada
- Jennifer Scott
- Heartland Fertility & Gynecology Clinic
- Gordon McTavish
- Heartland Fertility & Gynecology Clinic
- Valerie Smid
- National Centre for Foreign Animal Disease, Canadian Food Inspection Agency
- Young K. Park
- GeneOne Life Science Inc.
- Joel N. Maslow
- GeneOne Life Science Inc.
- Niranjan Y. Sardesai
- Inovio Pharmaceuticals Inc.
- J. Joseph Kim
- Inovio Pharmaceuticals Inc.
- Xiao-jian Yao
- Department of Medical Microbiology and Infectious Diseases, University of Manitoba
- Alexander Bello
- Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada
- Robbin Lindsay
- Department of Medical Microbiology and Infectious Diseases, University of Manitoba
- Guy Boivin
- Research Center in Infectious Diseases of the CHU of Québec and Laval University
- Stephanie A. Booth
- Department of Medical Microbiology and Infectious Diseases, University of Manitoba
- Darwyn Kobasa
- Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada
- Carissa Embury-Hyatt
- National Centre for Foreign Animal Disease, Canadian Food Inspection Agency
- David Safronetz
- Department of Medical Microbiology and Infectious Diseases, University of Manitoba
- David B. Weiner
- The Wistar Institute
- Gary P. Kobinger
- Department of Microbiology and Immunology, Faculty of Medicine, Laval University
- DOI
- https://doi.org/10.1038/ncomms15743
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 8
Abstract
Zika virus (ZIKV) can persist in human semen and sperm, which can result in sexual transmission. Here, Griffinet al. show that a DNA vaccine, expressing ZIKV pre-membrane and envelope proteins, protects mice from infection-associated damage to testes and sperm, and prevents viral persistence in testes.
