Dermatology Reports (Aug 2021)

Treatment of periocular advanced basal cell carcinoma with Hedgehog pathway inhibitors: a single-center study and a new dedicated therapeutic protocol

  • Vincenzo De Giorgi,
  • Luciana Trane,
  • Giulia Pieretti,
  • Nicola Santoro,
  • Flavia Silvestri ,
  • Federico Venturi,
  • Federica Scarfi,
  • Vincenza Maio,
  • Giuseppe Spinelli,
  • Silvia Scoccianti,
  • Laura Guerrini,
  • Daniela Massi,
  • Cinzia Mazzini,
  • Laura Doni

DOI
https://doi.org/10.4081/dr.2021.9240

Abstract

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Background: The management of difficult-to-treat periocular basal cell carcinoma becomes very challenging in cases of delayed diagnosis, leading to the development of locally advanced basal cell carcinoma. Objective: The aim of this study was to evaluate the outcomes of Hedgehog pathway inhibitors (vismodegib and sonidegib) treatment in patients affected by periocular locally advanced basal cell carcinoma. We focused on the common adverse events and their correlation with the administration schedule in order to determine a management protocol specific for the periocular area. Methods: This observational prospective study included a single-center case series with patients who were histologically confirmed to have periocular or orbital locally advanced basal cell carcinoma, treated with Hedgehog pathway inhibitors. Results: All patients benefitted in terms of regression or stabilization of the neoplasm. In the first months of treatment, the HPIs were well tolerated, and the first important side effects appeared after about 5 months of continuous use of the drug. Conclusion: These data could lead to a new type of therapeutic scheme where neoadjuvant therapy could be followed by pulse therapy as an adjuvant to surgery.

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