Frontiers in Endocrinology (Oct 2021)
Association Between Age at Diagnosis of Type 2 Diabetes and Cardiovascular Diseases: A Nationwide, Population-Based, Cohort Study
- Chunyan Hu,
- Chunyan Hu,
- Lin Lin,
- Lin Lin,
- Yujing Zhu,
- Yi Zhang,
- Yi Zhang,
- Shuangyuan Wang,
- Shuangyuan Wang,
- Jie Zhang,
- Jie Zhang,
- Hongyan Qi,
- Hongyan Qi,
- Mian Li,
- Mian Li,
- Yuanyue Zhu,
- Yuanyue Zhu,
- Yanan Huo,
- Qin Wan,
- Yingfen Qin,
- Ruying Hu,
- Lixin Shi,
- Qing Su,
- Xuefeng Yu,
- Li Yan,
- Guijun Qin,
- Xulei Tang,
- Gang Chen,
- Min Xu,
- Min Xu,
- Yu Xu,
- Yu Xu,
- Tiange Wang,
- Tiange Wang,
- Zhiyun Zhao,
- Zhiyun Zhao,
- Zhengnan Gao,
- Guixia Wang,
- Feixia Shen,
- Zuojie Luo,
- Li Chen,
- Qiang Li,
- Zhen Ye,
- Yinfei Zhang,
- Chao Liu,
- Youmin Wang,
- Tao Yang,
- Huacong Deng,
- Lulu Chen,
- Tianshu Zeng,
- Donghui Li,
- Jiajun Zhao,
- Yiming Mu,
- Yufang Bi,
- Yufang Bi,
- Weiqing Wang,
- Weiqing Wang,
- Guang Ning,
- Guang Ning,
- Shengli Wu,
- Yuhong Chen,
- Yuhong Chen,
- Jieli Lu,
- Jieli Lu
Affiliations
- Chunyan Hu
- Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Chunyan Hu
- Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Lin Lin
- Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Lin Lin
- Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Yujing Zhu
- Department of Endocrinology, Karamay Municipal People’s Hospita , Xinjiang, China
- Yi Zhang
- Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Yi Zhang
- Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Shuangyuan Wang
- Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Shuangyuan Wang
- Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Jie Zhang
- Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Jie Zhang
- Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Hongyan Qi
- Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Hongyan Qi
- Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Mian Li
- Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Mian Li
- Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Yuanyue Zhu
- Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Yuanyue Zhu
- Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Yanan Huo
- Jiangxi Provincial People’s Hospital, Affiliated to Nanchang University, Nanchang, Xinjiang, China
- Qin Wan
- Department of Endocrinology, The Affiliated Hospital of Luzhou Medical College, Luzhou, China
- Yingfen Qin
- Department of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China
- Ruying Hu
- Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China
- Lixin Shi
- Department of Endocrinology, Affiliated Hospital of Guiyang Medical University, Guiyang, China
- Qing Su
- Xinhua Hospital, Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China
- Xuefeng Yu
- 0Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Li Yan
- 1Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China
- Guijun Qin
- 2Department of Endocrinology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Xulei Tang
- 3Department of Endocrinology, The First Hospital of Lanzhou University, Lanzhou, China
- Gang Chen
- 4Fujian Provincial Hospital, Fujian Medical University, Fuzhou, China
- Min Xu
- Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Min Xu
- Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Yu Xu
- Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Yu Xu
- Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Tiange Wang
- Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Tiange Wang
- Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Zhiyun Zhao
- Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Zhiyun Zhao
- Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Zhengnan Gao
- 5Dalian Municipal Central Hospital, Affiliated of Dalian Medical University, Dalian, China
- Guixia Wang
- 6Department of Endocrinology, The First Hospital of Jilin University, Changchun, China
- Feixia Shen
- 7Department of Endocrinology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China
- Zuojie Luo
- Department of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China
- Li Chen
- 8Qilu Hospital of Shandong University, Jinan, China
- Qiang Li
- 9Department of Endocrinology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China
- Zhen Ye
- Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China
- Yinfei Zhang
- 0Department of Endocrinology, Central Hospital of Shanghai Jiading District, Shanghai, China
- Chao Liu
- 1Department of Endocrinology, Jiangsu Province Hospital on Integration of Chinese and Western Medicine, Nanjing, China
- Youmin Wang
- 2Department of Endocrinology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
- Tao Yang
- 3Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
- Huacong Deng
- 4Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
- Lulu Chen
- 5Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Tianshu Zeng
- 5Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- Donghui Li
- 6Department of Gastrointestinal Medical Oncology, the University of Texas MD Anderson Cancer Center, Houston, TX, United States
- Jiajun Zhao
- 7Shandong Provincial Hospital, Affiliated to Shandong University, Jinan, China
- Yiming Mu
- 8Department of Endocrinology, Chinese People’s Liberation Army General Hospital, Beijing, China
- Yufang Bi
- Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Yufang Bi
- Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Weiqing Wang
- Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Weiqing Wang
- Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Guang Ning
- Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Guang Ning
- Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Shengli Wu
- Department of Endocrinology, Karamay Municipal People’s Hospita , Xinjiang, China
- Yuhong Chen
- Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Yuhong Chen
- Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Jieli Lu
- Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- Jieli Lu
- Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- DOI
- https://doi.org/10.3389/fendo.2021.717069
- Journal volume & issue
-
Vol. 12
Abstract
ObjectivesNationwide studies focusing on the impact of early-onset type 2 diabetes and obesity on the development of cardiovascular diseases (CVD) are limited in China. We aimed to investigate the association between age at diagnosis of type 2 diabetes and the risk of CVD, and to further examine the modifying effect of obesity on this association among Chinese adults.MethodsThis study included 23,961 participants with previously diagnosed diabetes from a large nationwide population-based cohort study across mainland China. With an interviewer-assisted questionnaire, we collected detailed information on CVDs. Logistic regression analysis was used to evaluate the risk of CVDs associated with age at diagnosis of diabetes.ResultsCompared with patients with late-onset diabetes (≥60 years), those with earlier-onset diabetes had increased risks for CVD, with adjusted ORs (95% CIs) of 1.72 (1.36-2.17), 1.52 (1.31-1.75) and 1.33 (1.19-1.48) for patients diagnosed aged <40, 40-49 and 50-59 years, respectively. Each 5-year earlier age at diagnosis of type 2 diabetes was significantly associated with 14% increased risk of CVD (OR, 1.14; 95%CI, 1.11-1.18). This association was more prominent for patients with obesity than those with normal body mass index (BMI). Significant interaction was detected between age at diagnosis and BMI categories on CVD risk (P for interaction=0.0457).ConclusionEarly-onset type 2 diabetes was significantly associated with higher risk of CVD, and this association was more prominent among patients with obesity.
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