MRAP2 regulates ghrelin receptor signaling and hunger sensing

Dollada Srisai; Terry C. Yin; Abigail A. Lee; Alix A. J. Rouault; Nicole A. Pearson; Justin L. Grobe; Julien A. Sebag

doi:10.1038/s41467-017-00747-6

Nature Communications (Sep 2017)

MRAP2 regulates ghrelin receptor signaling and hunger sensing

Dollada Srisai,
Terry C. Yin,
Abigail A. Lee,
Alix A. J. Rouault,
Nicole A. Pearson,
Justin L. Grobe,
Julien A. Sebag

Affiliations

Dollada Srisai: Department of Molecular Physiology and Biophysics, University of Iowa, Carver College of Medicine
Terry C. Yin: Department of Molecular Physiology and Biophysics, University of Iowa, Carver College of Medicine
Abigail A. Lee: Department of Molecular Physiology and Biophysics, University of Iowa, Carver College of Medicine
Alix A. J. Rouault: Department of Molecular Physiology and Biophysics, University of Iowa, Carver College of Medicine
Nicole A. Pearson: F.O.E.D.R.C
Justin L. Grobe: F.O.E.D.R.C
Julien A. Sebag: Department of Molecular Physiology and Biophysics, University of Iowa, Carver College of Medicine

DOI: https://doi.org/10.1038/s41467-017-00747-6
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 10

Abstract

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Melanocortin receptor accessory protein 2 (MRAP2) is an adaptor protein that contributes to melanocortin-4 receptor and prokineticin receptor 1 signalling. Here the authors show that MRAP2 also regulates ghrelin receptor signalling in the hypothalamus and starvation sensing in mice.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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