Nature Communications (Nov 2017)

piRNAs and Aubergine cooperate with Wispy poly(A) polymerase to stabilize mRNAs in the germ plasm

  • Jérémy Dufourt,
  • Gwénaëlle Bontonou,
  • Aymeric Chartier,
  • Camille Jahan,
  • Anne-Cécile Meunier,
  • Stéphanie Pierson,
  • Paul F. Harrison,
  • Catherine Papin,
  • Traude H. Beilharz,
  • Martine Simonelig

DOI
https://doi.org/10.1038/s41467-017-01431-5
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 12

Abstract

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In Drosophila embryos, Piwi-interacting RNAs (piRNAs) loaded into the PIWI protein Aubergine target and destabilize maternal mRNAs. Here, the authors provide evidence that piRNAs and Aubergine cooperate with the Wispy poly(A) polymerase to stabilize these mRNAs in the germ plasm.