Nature Communications (Mar 2016)

Elimination of HIV-1-infected cells by broadly neutralizing antibodies

  • Timothée Bruel,
  • Florence Guivel-Benhassine,
  • Sonia Amraoui,
  • Marine Malbec,
  • Léa Richard,
  • Katia Bourdic,
  • Daniel Aaron Donahue,
  • Valérie Lorin,
  • Nicoletta Casartelli,
  • Nicolas Noël,
  • Olivier Lambotte,
  • Hugo Mouquet,
  • Olivier Schwartz

DOI
https://doi.org/10.1038/ncomms10844
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 12

Abstract

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Broadly neutralizing antibodies (bNAbs) are promising as potential therapies targeting HIV-1 but their overall antiviral activity remains to be fully elucidated. Here the authors evaluate the ability of a panel of bNAbs to trigger antibody-dependent cellular cytotoxicity and identify the most effective antibody combinations.