RNA surveillance via nonsense-mediated mRNA decay is crucial for longevity in daf-2/insulin/IGF-1 mutant C. elegans

Heehwa G. Son; Mihwa Seo; Seokjin Ham; Wooseon Hwang; Dongyeop Lee; Seon Woo A. An; Murat Artan; Keunhee Seo; Rachel Kaletsky; Rachel N. Arey; Youngjae Ryu; Chang Man Ha; Yoon Ki Kim; Coleen T. Murphy; Tae-Young Roh; Hong Gil Nam; Seung-Jae V. Lee

doi:10.1038/ncomms14749

Nature Communications (Mar 2017)

RNA surveillance via nonsense-mediated mRNA decay is crucial for longevity in daf-2/insulin/IGF-1 mutant C. elegans

Heehwa G. Son,
Mihwa Seo,
Seokjin Ham,
Wooseon Hwang,
Dongyeop Lee,
Seon Woo A. An,
Murat Artan,
Keunhee Seo,
Rachel Kaletsky,
Rachel N. Arey,
Youngjae Ryu,
Chang Man Ha,
Yoon Ki Kim,
Coleen T. Murphy,
Tae-Young Roh,
Hong Gil Nam,
Seung-Jae V. Lee

Affiliations

Heehwa G. Son: Department of Life Sciences, Pohang University of Science and Technology
Mihwa Seo: Department of Life Sciences, Pohang University of Science and Technology
Seokjin Ham: Department of Life Sciences, Pohang University of Science and Technology
Wooseon Hwang: Department of Life Sciences, Pohang University of Science and Technology
Dongyeop Lee: Department of Life Sciences, Pohang University of Science and Technology
Seon Woo A. An: Department of Life Sciences, Pohang University of Science and Technology
Murat Artan: Information Technology Convergence Engineering, Pohang University of Science and Technology
Keunhee Seo: Department of Life Sciences, Pohang University of Science and Technology
Rachel Kaletsky: Department of Molecular Biology & LSI Genomics, Princeton University
Rachel N. Arey: Department of Molecular Biology & LSI Genomics, Princeton University
Youngjae Ryu: Research Division, Korea Brain Research Institute
Chang Man Ha: Research Division, Korea Brain Research Institute
Yoon Ki Kim: Creative Research Initiatives Center for Molecular Biology of Translation, Korea University
Coleen T. Murphy: Department of Molecular Biology & LSI Genomics, Princeton University
Tae-Young Roh: Department of Life Sciences, Pohang University of Science and Technology
Hong Gil Nam: Center for Plant Aging Research, Institute for Basic Science
Seung-Jae V. Lee: Department of Life Sciences, Pohang University of Science and Technology

DOI: https://doi.org/10.1038/ncomms14749
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 11

Abstract

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The decline of DNA and protein quality control contributes to organismal ageing. Here, Sonet al. report that nonsense-mediated mRNA decay, a RNA quality control mechanism, is enhanced in long-lived daf-2 mutant worms and contributes to their longevity by regulating expression of the yars-2/tyrosyl tRNA synthetase.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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