Shape-recovery of implanted shape-memory devices remotely triggered via image-guided ultrasound heating

Yang Zhu; Kaicheng Deng; Jianwei Zhou; Chong Lai; Zuwei Ma; Hua Zhang; Jiazhen Pan; Liyin Shen; Matthew D. Bucknor; Eugene Ozhinsky; Seungil Kim; Guangjie Chen; Sang-ho Ye; Yue Zhang; Donghong Liu; Changyou Gao; Yonghua Xu; Huanan Wang; William R. Wagner

doi:10.1038/s41467-024-45437-2

Nature Communications (Feb 2024)

Shape-recovery of implanted shape-memory devices remotely triggered via image-guided ultrasound heating

Yang Zhu,
Kaicheng Deng,
Jianwei Zhou,
Chong Lai,
Zuwei Ma,
Hua Zhang,
Jiazhen Pan,
Liyin Shen,
Matthew D. Bucknor,
Eugene Ozhinsky,
Seungil Kim,
Guangjie Chen,
Sang-ho Ye,
Yue Zhang,
Donghong Liu,
Changyou Gao,
Yonghua Xu,
Huanan Wang,
William R. Wagner

Affiliations

Yang Zhu: MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University
Kaicheng Deng: MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University
Jianwei Zhou: School of Electromechanical and Energy Engineering, NingboTech University
Chong Lai: Department of Urology, First Affiliated Hospital, School of Medicine, Zhejiang University
Zuwei Ma: McGowan Institute for Regenerative Medicine, University of Pittsburgh
Hua Zhang: College of Animal Sciences, Zhejiang University
Jiazhen Pan: College of Animal Sciences, Zhejiang University
Liyin Shen: MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University
Matthew D. Bucknor: Radiology and Biomedical Imaging, University of California
Eugene Ozhinsky: Radiology and Biomedical Imaging, University of California
Seungil Kim: McGowan Institute for Regenerative Medicine, University of Pittsburgh
Guangjie Chen: Department of Urology, The Children’s Hospital, School of Medicine, National Clinical Research Center for Child Health, Zhejiang University
Sang-ho Ye: McGowan Institute for Regenerative Medicine, University of Pittsburgh
Yue Zhang: San Francisco Veterans Affairs Medical Center, University of California
Donghong Liu: College of Biosystems Engineering and Food Science, National-Local Joint Engineering Laboratory of Intelligent Food Technology and Equipment, Zhejiang Key Laboratory for Agro-Food Processing, Zhejiang University
Changyou Gao: MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University
Yonghua Xu: Department of Imaging and Interventional Radiology, Zhongshan-Xuhui Hospital of Fudan University/Shanghai Xuhui Central Hospital
Huanan Wang: College of Animal Sciences, Zhejiang University
William R. Wagner: McGowan Institute for Regenerative Medicine, University of Pittsburgh

DOI: https://doi.org/10.1038/s41467-024-45437-2
Journal volume & issue: Vol. 15, no. 1
pp. 1 – 12

Abstract

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Abstract Shape-memory materials hold great potential to impart medical devices with functionalities useful during implantation, locomotion, drug delivery, and removal. However, their clinical translation is limited by a lack of non-invasive and precise methods to trigger and control the shape recovery, especially for devices implanted in deep tissues. In this study, the application of image-guided high-intensity focused ultrasound (HIFU) heating is tested. Magnetic resonance-guided HIFU triggered shape-recovery of a device made of polyurethane urea while monitoring its temperature by magnetic resonance thermometry. Deformation of the polyurethane urea in a live canine bladder (5 cm deep) is achieved with 8 seconds of ultrasound-guided HIFU with millimeter resolution energy focus. Tissue sections show no hyperthermic tissue injury. A conceptual application in ureteral stent shape-recovery reduces removal resistance. In conclusion, image-guided HIFU demonstrates deep energy penetration, safety and speed.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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