Nature Communications (Aug 2018)

mTOR-dependent phosphorylation controls TFEB nuclear export

  • Gennaro Napolitano,
  • Alessandra Esposito,
  • Heejun Choi,
  • Maria Matarese,
  • Valerio Benedetti,
  • Chiara Di Malta,
  • Jlenia Monfregola,
  • Diego Luis Medina,
  • Jennifer Lippincott-Schwartz,
  • Andrea Ballabio

DOI
https://doi.org/10.1038/s41467-018-05862-6
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 10

Abstract

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On amino acid deprivation TFEB translocates from the cytoplasm to the nucleus. Here the authors identify a nuclear export signal in TFEB that is recognized by the exportin CRM1, and show that dual phosphorylation at S142 and S138 by mTOR accelerates export of TFEB.