Mussel-inspired sulfated hyaluronan cryogel patch with antioxidant, anti-inflammatory, and drug-loading properties for multifunctional wound adhesives

Wonmoon Song; Young Hwan Choi; Young Gi Moon; Changyub Lee; M. Nivedhitha Sundaram; Nathaniel S. Hwang

Bioactive Materials (Oct 2024)

Mussel-inspired sulfated hyaluronan cryogel patch with antioxidant, anti-inflammatory, and drug-loading properties for multifunctional wound adhesives

Wonmoon Song,
Young Hwan Choi,
Young Gi Moon,
Changyub Lee,
M. Nivedhitha Sundaram,
Nathaniel S. Hwang

Affiliations

Wonmoon Song: School of Chemical and Biological Engineering, Institute for Chemical Processes, Seoul National University, Seoul, 08826, Republic of Korea; Interdisciplinary Program in Bioengineering, Seoul National University, Seoul, 08826, Republic of Korea
Young Hwan Choi: School of Chemical and Biological Engineering, Institute for Chemical Processes, Seoul National University, Seoul, 08826, Republic of Korea; Bio-MAX/N-Bio Institute, Institute of BioEngineering, Seoul National University, Seoul, 08826, Republic of Korea; Division of Pediatric Cardiac Surgery, Department of Surgery, Johns Hopkins School of Medicine, Baltimore, MD, USA
Young Gi Moon: School of Chemical and Biological Engineering, Institute for Chemical Processes, Seoul National University, Seoul, 08826, Republic of Korea
Changyub Lee: School of Chemical and Biological Engineering, Institute for Chemical Processes, Seoul National University, Seoul, 08826, Republic of Korea
M. Nivedhitha Sundaram: School of Chemical and Biological Engineering, Institute for Chemical Processes, Seoul National University, Seoul, 08826, Republic of Korea
Nathaniel S. Hwang: School of Chemical and Biological Engineering, Institute for Chemical Processes, Seoul National University, Seoul, 08826, Republic of Korea; Interdisciplinary Program in Bioengineering, Seoul National University, Seoul, 08826, Republic of Korea; Bio-MAX/N-Bio Institute, Institute of BioEngineering, Seoul National University, Seoul, 08826, Republic of Korea; Institute of Engineering Research, Seoul National University, Seoul, 08826, Republic of Korea; Corresponding author. School of Chemical and Biological Engineering, Seoul National University, Seoul, Republic of Korea.

Journal volume & issue: Vol. 40
pp. 582 – 596

Abstract

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Wounds, characterized by the disruption of the continuity of body tissues resulting from external trauma, manifest in diverse types and locations. Although numerous wound dressings are available for various wound scenarios, it remains challenging to find an integrative wound dressing capable of addressing diverse wound situations. We focused on utilizing sulfated hyaluronan (sHA), known for its anti-inflammatory properties and capacity to load cationic drugs. By conjugating catechol groups to sHA (sHA-CA), we achieved several advantages in wound healing: 1) Fabrication of patches through crosslinking with catechol-modified high-molecular-weight hyaluronan (HA(HMW)-CA), 2) Adhesiveness that enabled stable localization, 3) Radical scavenging that could synergize with the immunomodulation of sHA. The sHA-CA patches demonstrated therapeutic efficacy in three distinct murine wound models: diabetic wound, hepatic hemorrhage, and post-surgical adhesion. Collectively, these findings underscore the potential of the sHA-CA patch as a promising candidate for the next-generation wound dressing.

Published in Bioactive Materials

ISSN: 2452-199X (Online)
Publisher: KeAi Communications Co., Ltd.
Country of publisher: China
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering: Materials of engineering and construction. Mechanics of materials; Science: Biology (General)
Website: https://www.keaipublishing.com/en/journals/bioactive-materials/

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