Production of Carbapenemases in Klebsiella pneumoniae Isolated in Saint-Petersburg

Abstract

Carbapenem-resistant nosocomial K. pneumoniae isolates are a significant problem in clinical practice. Carbapenem resistance in K. pneumoniae isolated from hospitalized patients was 2.8% over the study period. NDM-1 carbapenemase-producing strains were the most prevalent ones. K. pneumoniae strains with OXA-48 were isolated more rarely, and KPC-2 was determined in 2 cases. NDM-1 gene was detected in multiple K. pneumoniae sequence types (ST340, ST147, ST11, ST307). OXA-48 gene was determined in K. pneumoniae ST395 and KPC-2 gene was determined in K. pneumoniae ST15 and ST258.

Keywords

• nosocomial infections
• k. pneumoniae
• antimicrobial resistance
• carbapenems
• ndm
• oxa-48
• kpc